Effect of preload on rat aortic smooth muscle sensitivity to vasoactive agents.
Effect of preload on rat aortic smooth muscle sensitivity to vasoactive agents.
复制标题
预负荷对大鼠主动脉平滑肌对血管活性药物敏感性的影响。
DOI：
10.1159/000138198
复制
发表时间：
1986
期刊：
影响因子：
3.1
通讯作者：
Berardo,PV
中科院分区：
文献类型：
--
作者：
Herlihy,JT;Berardo,PV
从大鼠主动脉条获得氯化钾、苯丙氨酸、5-羟色胺和氯化钙的浓度-反应曲线，所述主动脉条经受0.75、1.5或3.0g的预负荷。主动脉平滑肌对氯化钾、苯肾上腺素和5-羟色胺的敏感性随前负荷的增加而增加;而K+去极化条的氯化钙浓度-反应曲线不受前负荷的影响。这些结果表明，大鼠主动脉平滑肌对许多血管活性剂的敏感性是前负荷的函数，也表明外部Ca 2+内流的改变不足以解释前负荷对敏感性的影响。
Concentration-response curves to potassium chloride, phenylephrine, serotonin and calcium chloride were obtained from rat aortic strips subjected to preloads of 0.75, 1.5 or 3.0 g. The sensitivity of the aortic smooth muscle to potassium chloride, phenylephrine and serotonin increased with increasing preload; whereas the calcium chloride concentration-response curves of K+-depolarized strips were unaffected by preload. These results demonstrate that the sensitivity of rat aortic smooth muscle to many vasoactive agents is a function of preload and also indicate that an alteration in the influx of external Ca2+is not sufficient to explain the effect of preload on sensitivity.