TETHERED IP3. SYNTHESIS AND BIOCHEMICAL APPLICATIONS OF THE 1-O-(3-AMINOPROPYL) ESTER OF INOSITOL 1,4,5-TRISPHOSPHATE
TETHERED IP3. SYNTHESIS AND BIOCHEMICAL APPLICATIONS OF THE 1-O-(3-AMINOPROPYL) ESTER OF INOSITOL 1,4,5-TRISPHOSPHATE
复制标题
系留 IP3。
DOI：
10.1021/ja00005a055
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发表时间：
1991
影响因子：
15
通讯作者：
S. Snyder
中科院分区：
文献类型：
--
作者：
G. Prestwich;J. Marecek;R. Mourey;A. Theibert;C. D. Ferris;S. Danoff;S. Snyder
合成了第二信使Ins（1，4，5）P3的磷酸二酯类似物，并用于制备新型光亲和标记物和选择性生物亲和基质。选择性保护的肌醇前体首先通过亚磷酸酯化学转化为N-保护的1-O-（3-氨丙基-1-磷酸基）-DL-肌醇，然后磷酸化以得到完全苄基化的IP 3衍生物。氢解得到标题化合物，将其转化为光不稳定的类似物并固定在聚合物树脂上
A phosphodiester analogue of the second messenger Ins (1,4,5)P 3 has been synthesized and used to prepare a novel photoaffinity label and a selective bioaffinity matrix. A selectively protected inositol precursor was first converted by phosphite ester chemistry to an N-protected 1-O-(3-aminopropyl-1-phospho)-DL-myo-inositol and then phosphorylated to give a fully benzylated IP 3 derivative. Hydrogenolysis gives the title compound, which was converted to a photolabile analogue and was immobilized on a polymeric resin