GALANIN BLOCKS THE SLOW CHOLINERGIC EPSP IN CA1 PYRAMIDAL NEURONS FROM VENTRAL HIPPOCAMPUS
GALANIN BLOCKS THE SLOW CHOLINERGIC EPSP IN CA1 PYRAMIDAL NEURONS FROM VENTRAL HIPPOCAMPUS
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DOI：
10.1016/0014-2999(89)90477-9
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发表时间：
1989-05-19
影响因子：
5
通讯作者：
NICOLL, RA
中科院分区：
文献类型：
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作者：
DUTAR, P;LAMOUR, Y;NICOLL, RA
利用切片制备的细胞内记录，我们研究了肽丙氨酸对大鼠腹侧海马CA1锥体神经元性质的影响。加丙氨酸在超滤介质中，对膜电位或后超极化的影响微弱且不一致。甘丙肽定位于中隔-海马通路的部分胆碱能神经元，不影响乙酰胆碱或氨基乙醇对CA1锥体神经元的作用。然而，它确实对胆碱能末端有突触前抑制作用，阻断内源性乙酰胆碱释放诱导的慢胆碱能兴奋突触后电位（EPSP）。这种效果是可逆的，阿托品可以模仿这种效果。这些结果表明肽甘丙肽与乙酰胆碱共定位在某些中隔海马神经元中可能在控制乙酰胆碱释放中起作用。
Using intracellular recordings from slice preparations, we studied the effects of the peptide galanin on the properties of CA1 pyramidal neurons from rat ventral hippocampus. Galanin, applied in the superfusing medium, had a weak and inconsistent effect on the membrane potential or on the afterhyperpolarization which follows a train of spikes. Galanin, which is localized in some cholinergic neurons of the septo-hippocampal pathway, did not affect the action of acetylcholine or carbachol on CA1 pyramidal neurons. However, it did have a presynaptic inhibitory effect on the cholinergic terminals, blocking the slow cholinergic excitatory post-synaptic potential (EPSP) induced by the release of endogenous acetylcholine on the pyramidal neurons. This effect was reversible and mimicked by atropine. These results suggest that the peptide galanin, colocalized with acetylcholine in some septo-hippocampal neurons might play a role in the control of acetylcholine release.