Antigen-specific proliferation and interferon-γ and interleukin-5 production are down-regulated during Schistosoma haematobium infection
Antigen-specific proliferation and interferon-γ and interleukin-5 production are down-regulated during Schistosoma haematobium infection
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DOI：
10.1086/517832
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发表时间：
1998-05-01
影响因子：
6.4
通讯作者：
Yazdanbakhsh, M
中科院分区：
文献类型：
--
作者：
Grogan, JL;Kremsner, PG;Yazdanbakhsh, M
本文对17例曾感染过埃及血吸虫的病人和20例化疗后2年未感染或再感染的病人进行了抗原特异性细胞免疫反应的检测。未感染者对成虫抗原的增殖率（AWA）明显高于再感染者（P = .02），而可溶性虫卵抗原（SEA）的反应在两组中仍然很低。未感染者对AWA和SEA产生的白细胞介素（IL）-5高于感染者（分别为P = 0.05和P <0.001），而IL-4和IL-13的释放在两组中相似。AWA和SEA的干扰素-γ水平与产蛋量呈负相关（分别为P = 0.03和P = 0.02）。这些数据表明，溶酶体感染的存在导致T细胞增殖性低反应性，并且典型的Th 1和Th 2细胞因子都可以通过活动性感染下调。
Antigen-specific cellular immune responses were examined in persons previously infected with Schistosoma haematobium and who were, 2 years after chemotherapy, either free from infection (n = 17) or reinfected (n = 20), Proliferation to adult worm antigen (AWA) was significantly higher in uninfected than in reinfected subjects (P = .02), whereas responses to soluble egg antigen (SEA) remained low in both groups. Interleukin (IL)-5 production in uninfected persons in response to AWA and SEA was higher than in infected subjects (P =.05 and P < .001, respectively), while IL-4 and IL-13 release was similar in the 2 groups. Levels of interferon-gamma to AWA and to SEA were inversely correlated with egg output (P =.03 and P =.02, respectively). These data indicate that the presence of schistosome infection leads to T cell proliferative hyporesponsiveness and that both typical Th1 and Th2 cytokines can be down-regulated by active infection.