Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition.
Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition.
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DOI：
10.1080/14622200125450
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发表时间：
2001-02
期刊：
影响因子：
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通讯作者：
T. Gould;A. C. Collins;J. M. Wehner
中科院分区：
文献类型：
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作者：
T. Gould;A. C. Collins;J. M. Wehner
酒精和尼古丁是经常一起使用的滥用药物。这种联合给药的一种可能解释是尼古丁预防或减轻了酒精相关的损伤。本研究检查了急性给予尼古丁、酒精或酒精加尼古丁对C57 BL/6小鼠中潜伏性抑制的剂量依赖性影响，通过舔抑制来测量。舔抑制率的变化进行了测量，通过评估10个预暴露于听觉条件刺激（CS）的影响，形成随后的CS休克非条件刺激（US）协会。预期预先暴露于CS的小鼠会产生较弱的CS-US关联。尼古丁前预暴露于CS产生的抑制率增加，乙醇前预暴露于CS抑制率降低，尼古丁逆转了乙醇的影响时，两种药物联合给药。尼古丁和乙醇的这些相反作用可能与人类吸烟和饮酒的高发病率有关。
Alcohol and nicotine are drugs of abuse that are used frequently together. One possible explanation for this co-administration is that nicotine prevents or lessens alcohol-associated impairments. The present study examined the dose-dependent effects of acute administration of nicotine, alcohol, or alcohol plus nicotine on latent inhibition as measured by lick suppression in C57BL/6 mice. Alterations in a lick suppression ratio were measured by assessing the effects of 10 pre-exposures to an auditory conditioned stimulus (CS) on formation of subsequent CS-shock unconditioned stimulus (US) associations. Mice pre-exposed to the CS were expected to develop a weaker CS-US association. Nicotine administered prior to pre-exposure to the CS produced increased suppression ratios, ethanol given prior to pre-exposure to the CS decreased suppression ratios, and nicotine reversed the effects of ethanol when the two drugs were co-administered. These opposing actions of nicotine and ethanol may have relevance to the high incidence of smoking and drinking in humans.