Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress
Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress
复制标题
熊果酸通过减轻内质网应激抑制非酒精性脂肪肝的发展
DOI：
10.1039/c5fo00083a
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发表时间：
2015-01-01
期刊：
影响因子：
6.1
通讯作者：
Zheng, Ling
中科院分区：
文献类型：
--
作者：
Li, Jian-Shuang;Wang, Wen-Jun;Zheng, Ling
熊果酸（UA）是一种天然的五环三萜化合物，富含许多草药和植物，如苹果、蔓越莓和橄榄。UA具有抗氧化、抗炎、抗癌、保肝等多种生物活性。然而，UA保护肝脏活性的确切机制尚不清楚。在这项研究中，UA对非酒精性脂肪性肝病（NAFLD）发展的影响进行了研究。在体内，UA （0.14%, w/w）显著降低了db/db小鼠（2型糖尿病小鼠模型）的肝脏重量、血清ALT/AST水平和肝脏脂肪变性。在体外，UA处理（10-30 μ g ml(-1)）显著降低棕榈酸诱导的L02细胞内脂质积累。我们的研究结果表明，UA对NAFLD的有益作用可能是由于其增加脂质β氧化和抑制肝内质网（ER）应激的能力。总之，UA可以进一步被认为是治疗NAFLD的天然化合物。
Ursolic acid (UA) is a natural pentacyclic triterpenoid compound, which is enriched with many herbs and plants, such as apple, cranberry and olive. UA performs multiple biological activities including anti-oxidation, anti-inflammation, anti-cancer and hepatoprotection. However, the exact mechanism underlying the hepatoprotective activity of UA remains unclear. In this study, the effects of UA on the development of nonalcoholic fatty liver disease (NAFLD) were investigated. In vivo, UA treatment (0.14%, w/w) significantly decreased the liver weight, serum levels of ALT/AST and hepatic steatosis in db/db mice (a type 2 diabetic mouse model). In vitro, UA treatment (10-30 mu g ml(-1)) significantly decreased palmitic acid induced intracellular lipid accumulation in L02 cells. Our results suggested that the beneficial effects of UA on NAFLD may be due to its ability to increase lipid beta-oxidation and to inhibit the hepatic endoplasmic reticulum (ER) stress. Together, UA may be further considered as a natural compound for NAFLD treatment.