Pseudo-Five-Component Reaction for Diastereoselective Synthesis of Butterfly Shaped Bispiro[Oxindole-Pyrrolidine]s.
Pseudo-Five-Component Reaction for Diastereoselective Synthesis of Butterfly Shaped Bispiro[Oxindole-Pyrrolidine]s.
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DOI：
10.1021/acs.joc.1c01797
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Xiaofeng Zhang;W. Qiu;S. Murray;Desheng Zhan;Jason J Evans;J. Jasinski;Xiao Wang;Wei Zhang
中科院分区：
文献类型：
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作者：
Xiaofeng Zhang;W. Qiu;S. Murray;Desheng Zhan;Jason J Evans;J. Jasinski;Xiao Wang;Wei Zhang
研究了亚甲亚胺叶立德与含氧吲哚类化合物的双脱羧基1，3偶极环加成反应，用于非对映选择性合成双螺并[氧吲哚-吡咯烷]S。主要的非对映异构体是具有对称面的独特的蝴蝶状化合物。反应采用可回收分子筛HY酸催化剂，副产物只有CO2和H2O。
A pseudo-five-component reaction involving double decarboxylative 1,3-dipolar cycloaddition of azomethine ylides with olefinic oxindoles for the diastereoselective synthesis of bispiro[oxindole-pyrrolidine]s is developed. The major diastereomers are unique butterfly shaped compounds with a plane of symmetry. Recyclable zeolite HY acid catalyst is used to promote the reaction, and only CO2 and H2O are generated as byproducts.