A strain-absorbing design for tissue-machine interfaces using a tunable adhesive gel
A strain-absorbing design for tissue-machine interfaces using a tunable adhesive gel
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DOI：
10.1038/ncomms6898
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发表时间：
2014-12-01
影响因子：
16.6
通讯作者：
Someya, Takao
中科院分区：
文献类型：
--
作者：
Lee, Sungwon;Inoue, Yusuke;Someya, Takao
为了测量人体的电生理信号，必须在目标生物组织和电探针之间建立稳定、温和且无过敏的接触。然而，很难在两者之间长期形成稳定的界面，特别是当生物组织的表面潮湿和/或组织表现出运动时。在这里，我们通过设计和制造智能、压力吸收电子设备来解决这个难题，这些电子设备可以粘附在潮湿和复杂的组织表面上，并可以对生命信号进行可靠、长期的测量。我们展示了一个多电极阵列，它可以附着在大鼠心脏的表面，从而产生超过 3 小时的良好保形接触。此外，我们还展示了使用类似设计的高灵敏度、可拉伸应变传感器阵列。具有增强组织粘附力的超柔性电子器件可以在未来长期体内生物信号监测中得到应用。
To measure electrophysiological signals from the human body, it is essential to establish stable, gentle and nonallergic contacts between the targeted biological tissue and the electrical probes. However, it is difficult to form a stable interface between the two for long periods, especially when the surface of the biological tissue is wet and/or the tissue exhibits motion. Here we resolve this difficulty by designing and fabricating smart, stress-absorbing electronic devices that can adhere to wet and complex tissue surfaces and allow for reliable, long-term measurements of vital signals. We demonstrate a multielectrode array, which can be attached to the surface of a rat heart, resulting in good conformal contact for more than 3 h. Furthermore, we demonstrate arrays of highly sensitive, stretchable strain sensors using a similar design. Ultra-flexible electronics with enhanced adhesion to tissue could enable future applications in chronic in vivo monitoring of biological signals.