Corticospinal Tract Pre-Wallerian Degeneration A Novel Outcome Predictor for Pediatric Stroke on Acute MRI
Corticospinal Tract Pre-Wallerian Degeneration A Novel Outcome Predictor for Pediatric Stroke on Acute MRI
复制标题
DOI：
10.1161/strokeaha.108.529958
复制
发表时间：
2009-03-01
期刊：
影响因子：
8.3
通讯作者：
Kirton, Adam
中科院分区：
文献类型：
--
作者：
Domi, Trish;deVeber, Gabrielle;Kirton, Adam
背景和目的：在新生儿动脉缺血性卒中中，弥散MRI（DWI）上皮质脊髓降束（DCST）的沃勒变性前预示预后不良。这个信号还没有被研究在大龄child.Methods-A连续动脉缺血性中风队列（1个月至18岁）急性DWI和>12个月的后续登记（SickKids儿童中风计划）。DCST-DWI变量进行了量化与一个有效的软件技术和相关性的儿科中风结局measured were searched.Results-Abnormal DCST-DWI信号检测20 29名儿童（69%），与85%的运动缺陷的儿科中风结局措施。与轻偏瘫相关的DCST变量包括：（1）DCST过程中的任何异常信号;（2）中脑位置;（3）脚百分比;（4）垂直长度;（5）受累的相对体积（均P
Background and Purpose-In neonatal arterial ischemic stroke, pre-Wallerian degeneration in descending corticospinal tracts (DCST) on diffusion MRI (DWI) predicts poor outcome. This signal has not been studied in older children.Methods-A consecutive arterial ischemic stroke cohort (1 month to 18 years) with acute DWI and >12 months of follow-up were enrolled (SickKids Children's Stroke Program). DCST-DWI variables were quantified with a validated software technique and correlations to the Pediatric Stroke Outcome Measure were sought.Results-Abnormal DCST-DWI signal was detected in 20 of 29 children (69%), with 85% having motor deficits on Pediatric Stroke Outcome Measure. DCST variables correlated with hemiparesis included: (1) any abnormal signal within the course of the DCST; (2) midbrain location; (3) percentage of peduncle; (4) vertical length; and (5) relative volume affected (all P