Whole body and muscle respiratory capacity with dobutamine and hindlimb suspension.
Whole body and muscle respiratory capacity with dobutamine and hindlimb suspension.
复制标题
全身和肌肉呼吸能力与多巴酚丁胺和后肢悬挂。
DOI：
10.1152/jappl.1991.71.6.2419
复制
发表时间：
1991
影响因子：
3.3
通讯作者：
H. Hoppeler
中科院分区：
文献类型：
--
作者：
D. Desplanches;R. Favier;B. Sempore;H. Hoppeler
重复注射多巴酚丁胺（一种合成的儿茶酚胺）的效果在对照组和尾吊大鼠中进行了研究，以确定这种药物是否可以改善失重的代谢反应。多巴酚丁胺可防止后肢悬吊引起的最大摄氧量（VO2max）降低。此外，多巴酚丁胺治疗组动物的最大摄氧量比生理盐水治疗对照组动物高12%。比目鱼肌重量和平均纤维横截面积分别下降了60%和75%，分别在生理盐水和多巴酚丁胺治疗的悬浮大鼠。总毛细血管长度不受减重的影响，在所有接受多巴酚丁胺的动物中增加了21%。该药物阻止了由减重诱导的总线粒体体积密度增加（+30%），但不改变总线粒体体积。我们的研究结果表明，1）多巴酚丁胺是有用的，以防止总有氧能力的下降，在后肢悬挂，2）多巴酚丁胺增加VO2max在对照组大鼠，和3）总毛细血管长度增加比目鱼肌在所有组的药物，虽然没有有利的影响，可以检测到线粒体。
The effects of repeated injections of dobutamine, a synthetic catecholamine, were studied in control and tail-suspended rats to determine whether this drug could improve the metabolic response to unweighting. Dobutamine prevented the decrease in maximal oxygen uptake (VO2max) induced by hindlimb suspension. Furthermore, VO2max was 12% greater in dobutamine-treated animals than in saline-treated control animals. Soleus muscle weight and mean fiber cross-sectional area were decreased by 60 and 75%, respectively, in saline- and dobutamine-treated suspended rats. Total capillary length was unaffected by unweighting and increased 21% in all animals receiving dobutamine. The drug prevented the increase in total mitochondrial volume density (+30%) induced by unweighting but did not change total mitochondrial volume. Our results suggest that 1) dobutamine is useful to prevent the decrease of total aerobic capacity during hindlimb suspension, 2) dobutamine increases VO2max in control rats, and 3) total capillary length in soleus muscle is increased by the drug in all groups, although no beneficial effects on mitochondria can be detected.