Genetic lineage tracing identifies endocardial origin of liver vasculature
Genetic lineage tracing identifies endocardial origin of liver vasculature
复制标题
遗传谱系追踪识别肝血管系统的心内膜起源
DOI：
10.1038/ng.3536
复制
发表时间：
2016
期刊：
影响因子：
30.8
通讯作者：
Zhou Bin
中科院分区：
文献类型：
--
作者：
Zhang Hui;Pu Wenjuan;Tian Xueying;Huang Xiuzhen;He Lingjuan;Liu Qiaozhen;Li Yan;Zhang Libo;He Liang;Liu Kuo;Gillich Astrid;Zhou Bin
肝血管系统对于肝脏的发育、内环境稳定和再生是必不可少的，然而肝血管形成的发育程序和肝血管系统的胚胎起源仍然未知。在这里，我们表明，在小鼠内皮细胞形成一个原始的血管丛周围的肝芽，并随后作出贡献的一个相当大的一部分肝脏血管。利用交叉遗传学，我们证明静脉窦的内膜是肝丛的来源。内皮细胞血管生成的抑制导致内皮细胞对肝血管系统的贡献减少和肝器官发生缺陷。我们的结论是，很大一部分的肝血管来自内皮细胞和冠状动脉共享一个共同的发展起源。
The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the developmental program of hepatic vessel formation and the embryonic origin of the liver vasculature remain unknown. Here we show in mouse that endocardial cells form a primitive vascular plexus surrounding the liver bud and subsequently contribute to a substantial portion of the liver vasculature. Using intersectional genetics, we demonstrate that the endocardium of the sinus venosus is a source for the hepatic plexus. Inhibition of endocardial angiogenesis results in reduced endocardial contribution to the liver vasculature and defects in liver organogenesis. We conclude that a substantial portion of liver vessels derives from the endocardium and shares a common developmental origin with coronary arteries.