Impact of Nodal Status and Tumor Burden in Sentinel Lymph Nodes on the Clinical Outcomes of Cancer Patients
Impact of Nodal Status and Tumor Burden in Sentinel Lymph Nodes on the Clinical Outcomes of Cancer Patients
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DOI：
10.1002/jso.21815
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发表时间：
2011-05-01
影响因子：
2.5
通讯作者：
Saha, Sukamal
中科院分区：
文献类型：
--
作者：
Leong, Stanley P. L.;Zuber, Markus;Saha, Sukamal
前哨淋巴结（SLN）概念在黑色素瘤和乳腺癌中的验证建立了癌症转移的新范式，一般来说，癌细胞以有序的方式从原发部位扩散到区域淋巴结盆地的前哨淋巴结，然后扩散到远处部位。在这篇综述文章中，我们探讨了 SLN 概念在阴茎癌、黑色素瘤和乳腺癌中的发展及其在其他实体癌中的应用，重点介绍了 SLN 微转移与临床结果之间的关系。 J.外科医生。安科尔。 2011；103：518-530。 (C) 2011 Wiley-Liss, Inc.
The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes. J. Surg. Oncol. 2011;103:518-530. (C) 2011 Wiley-Liss, Inc.