The cell biology of infection by intracellular bacterial pathogens.
The cell biology of infection by intracellular bacterial pathogens.
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细胞内细菌病原体感染的细胞生物学。
DOI：
10.1146/annurev.cb.11.110195.001241
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发表时间：
1995
影响因子：
11.3
通讯作者：
Theriot,JA
中科院分区：
文献类型：
--
作者：
Theriot,JA
单核细胞增生李斯特菌和福氏志贺菌是不相关的细菌病原体，它们在受感染的宿主动物体内独立进化出相似的生存策略。细菌与上皮细胞表面接触会诱导细胞骨架重排，导致吞噬作用。然后它们分泌酶降解吞噬体膜，将细菌释放到宿主细胞质中。胞质内细菌与由宿主细胞肌动蛋白丝组成的“彗星尾巴”一起快速移动。当移动的细菌到达细胞边缘时，它们会推出长的突起，细菌在尖端，然后被相邻的细胞吸收，使感染从细胞扩散到细胞。本文综述了目前已知的细菌和宿主之间的相互作用在感染的每个阶段，并讨论了哺乳动物细胞生物学家可以通过研究细菌病原体。
Listeria monocytogenes and Shigella flexneri are unrelated bacterial pathogens that have independently evolved similar strategies of survival within an infected host animal. Bacteria coming into contact with the surface of an epithelial cell induce cytoskeletal rearrangements resulting in phagocytosis. They then secrete enzymes that degrade the phagosomal membrane, releasing the bacteria into the host cytoplasm. Intracytoplasmic bacteria move rapidly, in association with a" comet tail" made up of host cell actin filaments. When moving bacteria reach the cell margin, they push out long protrusions with the bacteria at the tips that are then taken up by neighboring cells, allowing the infection to spread from cell to cell. This review summarizes what is currently known about the interactions between the bacteria and the host at each stage of the infection and discusses what mammalian cell biologists can learn by studying bacterial pathogens.