Anticipation of monetary gain but not loss in healthy older adults
Anticipation of monetary gain but not loss in healthy older adults
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DOI：
10.1038/nn1894
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发表时间：
2007-06-01
影响因子：
25
通讯作者：
Knutson, Brian
中科院分区：
文献类型：
--
作者：
Samanez-Larkin, Gregory R.;Gibbs, Sasha E. B.;Knutson, Brian
尽管在衰老的人类大脑中已经记录了整体结构的下降，但人们对老年人在激励处理过程中纹状体和前额叶皮层的功能完整性知之甚少。我们使用事件相关的功能磁共振成像来确定年轻人和老年人对预期金钱收益和损失的自我报告和神经反应是否存在差异。本研究提供了随着年龄的增长，纹状体和岛叶在获得预期期间完整激活的证据，但显示在损失预期期间激活相对减少。这些发现表明，老年人在处理得失时存在不对称性，这可能会对决策产生影响。
Although global declines in structure have been documented in the aging human brain, little is known about the functional integrity of the striatum and prefrontal cortex in older adults during incentive processing. We used event-related functional magnetic resonance imaging to determine whether younger and older adults differed in both self-reported and neural responsiveness to anticipated monetary gains and losses. The present study provides evidence for intact striatal and insular activation during gain anticipation with age, but shows a relative reduction in activation during loss anticipation. These findings suggest that there is an asymmetry in the processing of gains and losses in older adults that may have implications for decision-making.