Disinhibition of short-latency but not long-latency afferent inhibition of the lower limb during upper-limb muscle contraction
Disinhibition of short-latency but not long-latency afferent inhibition of the lower limb during upper-limb muscle contraction
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DOI：
10.1097/wnr.0000000000001889
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发表时间：
2023-03-22
期刊：
影响因子：
1.7
通讯作者：
Nakazawa，Kimitaka
中科院分区：
文献类型：
--
作者：
Kato，Tatsuya;Sasaki，Atsushi;Nakazawa，Kimitaka
研究表明，下肢的运动和感觉功能可以通过上肢肌肉收缩来调节。然而，下肢的感觉运动整合是否可以通过上肢肌肉收缩来调节仍然是未知的。[AQ：NR原创文章不需要结构化摘要。因此，删除了抽象的小节。请检查）。已经使用短潜伏期或长潜伏期传入抑制（分别为SAI或LAI）研究了人类感觉运动整合，所述传入抑制是指通过先前的外周感觉刺激经由经颅磁刺激引起的运动诱发电位（MEP）的抑制。在本研究中，我们的目的是调查是否上肢肌肉收缩可以调节下肢的感觉运动整合，通过检查SAI和LAI。在静息或自愿腕关节屈曲期间，以30（即SAI）、100和200 ms（即LAI）的刺激间间期（ISI）记录胫神经电刺激（Tendon）后的比目鱼肌MEP。比目鱼肌霍夫曼反射后Tendon也进行了测量，以确定是否MEP调制发生在皮层或脊髓水平。结果表明，下肢SAI，而不是LAI，在自愿屈腕解除抑制。此外，比目鱼肌霍夫曼反射后，在自愿屈腕Tendon是不变的，在任何ISI的静息状态相比。我们的研究结果表明，上肢肌肉收缩调节感觉运动的下肢整合和解除抑制下肢SAI在上肢肌肉收缩是基于皮质。
Research has demonstrated that motor and sensory functions of the lower limbs can be modulated by upper-limb muscle contractions. However, whether sensorimotor integration of the lower limb can be modulated by upper-limb muscle contractions is still unknown.[AQ: NR Original articles do not require structured abstracts. Hence, abstract subsections have been deleted. Please check.] Human sensorimotor integration has been studied using short-or long-latency afferent inhibition (SAI or LAI, respectively), which refers to inhibition of motor-evoked potentials (MEPs) elicited via transcranial magnetic stimulation by preceding peripheral sensory stimulation. In the present study, we aimed to investigate whether upper-limb muscle contractions could modulate the sensorimotor integration of the lower limbs by examining SAI and LAI. Soleus muscle MEPs following electrical tibial nerve stimulation (TSTN) during rest or voluntary wrist flexion were recorded at inter-stimulus intervals (ISIs) of 30 (ie SAI), 100, and 200 ms (ie LAI). The soleus Hoffman reflex following TSTN was also measured to identify whether MEP modulation occurred at the cortical or the spinal level. Results showed that lower-limb SAI, but not LAI, was disinhibited during voluntary wrist flexion. Furthermore, the soleus Hoffman reflex following TSTN during voluntary wrist flexion was unchanged when compared with that during the resting state at any ISI. Our findings suggest that upper-limb muscle contractions modulate sensorimotor integration of the lower limbs and that disinhibition of lower-limb SAI during upper-limb muscle contractions is cortically based.