HD2 proteins interact with RPD3-type histone deacetylases
HD2 proteins interact with RPD3-type histone deacetylases
复制标题
HD2 蛋白与 RPD3 型组蛋白脱乙酰酶相互作用
DOI：
10.4161/psb.20044
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Wu, Keqiang
中科院分区：
文献类型：
--
作者：
Luo, Ming;Wang, Yu-Yuan;Wu, Keqiang
HD2 蛋白先前被鉴定为植物特异性组蛋白脱乙酰酶 (HDAC)。 HD2蛋白功能的分子机制仍不清楚。使用双分子荧光互补测定，我们证明拟南芥 HD2 蛋白 HD2A、HD2C 和 HD2D 可以与 RPD3 型 HDAC、HDA6 和 HDA19 相互作用，表明这些蛋白可能在同一蛋白复合物中发挥作用。我们的研究表明，HD2 蛋白可能与 RPD3 型 HDAC 功能性相关，以调节植物中的基因表达。
HD2 proteins were previously identified as plant specific histone deacetylases (HDACs). The molecular mechanism of the function of HD2 proteins is still unclear. Using Bimolecular fluorescence complementation assay, we demonstrated that Arabidopsis HD2 proteins, HD2A, HD2C and HD2D, can interact with RPD3-type HDACs, HDA6 and HDA19, suggesting that that these proteins may act in the same protein complex. Our study indicates that HD2 proteins may functionally associate with RPD3-type HDACs to regulate gene expression in plants.