Incidence of stroke is related to carotid IMT even in the absence of plaque
Incidence of stroke is related to carotid IMT even in the absence of plaque
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DOI：
10.1016/j.atherosclerosis.2004.10.015
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发表时间：
2005-04-01
期刊：
影响因子：
5.3
通讯作者：
Hedblad, B
中科院分区：
文献类型：
--
作者：
Rosvall, M;Janzon, L;Hedblad, B
背景：颈动脉内膜-中层厚度(IMT)与卒中的发生有关。这种关联是否独立于颈动脉斑块是有争议的。方法和结果：B型超声确定颈总动脉IMT、颈动脉斑块(局灶性IMT和GT；1.2 mm)和卒中事件之间的关联。对5163名瑞典中年男性和女性进行了调查，平均随访时间为7年。调整了年龄和性别的颈动脉IMT。颈动脉斑块与未来卒中显著相关(p<；0.05)。对心血管危险因素的调整通常会降低风险比率，然而，在颈动脉斑块测量方面，这一点比IMT更显著。在校正了颈动脉斑块的存在后，颈动脉IMT与卒中的相关性仍然存在，在有颈动脉斑块和无颈动脉斑块的患者中，颈动脉IMT与卒中的分级相关。结论：在这项基于人群的研究中，颈总动脉IMT与卒中的发病率有关。这种关系与颈动脉斑块的存在无关。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
Background: The carotid intima-media thickness (IMT) has been associated with incidence of stroke. Whether this association is independent of carotid plaque is controversial.Methods and results: The associations among B-mode ultrasound determined common carotid IMT, carotid plaque (focal IMT > 1.2 mm) and incident stroke. were investigated in 5 163 Swedish middle-aged men and women over a median follow-up of 7 years. Age and sex-adjusted carotid IMT. and carotid plaque were significantly (p < 0.05) related to future stroke. Adjustment for cardiovascular risk factors generally reduced the hazard rate ratios, however more prominently so with regard to the carotid measure of plaque than with IMT. The associations between carotid IMT and stroke remained after adjustment for presence of carotid plaque, and graded associations between carotid IMT and stroke was found both among those with and without carotid plaque.Conclusions: In this population-based study, common carotid IMT was associated with incidence of stroke. This relation was independent of presence of carotid plaque. (c) 2004 Elsevier Ireland Ltd. All rights reserved.