GENETIC ASSOCIATION OF MATING TYPES AND VIRULENCE IN CRYPTOCOCCUS-NEOFORMANS
GENETIC ASSOCIATION OF MATING TYPES AND VIRULENCE IN CRYPTOCOCCUS-NEOFORMANS
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DOI：
10.1128/iai.60.2.602-605.1992
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发表时间：
1992-02-01
影响因子：
3.1
通讯作者：
WICKES, BL
中科院分区：
文献类型：
--
作者：
KWONCHUNG, KJ;EDMAN, JC;WICKES, BL
一对同源的新生隐球菌变种。构建了可能仅在交配型上不同的新型菌株B-4476（交配型）和B-4500（α-交配型）。这一对和他们的后代，五个α型和五个a型，在小鼠中进行了毒力测试。在亲本菌株以及后代中，α型明显比a型更具毒性。此外，与由a菌株引起的感染而死亡的小鼠相比，在α菌株感染的小鼠中死亡倾向于更早发生。这些数据有力地表明，在这种人类真菌病原体的毒力与交配型的遗传关联。
A pair of congenic Cryptococcus neoformans var. neoformans strains, B-4476 (a mating type) and B-4500 (alpha-mating type), that presumably differ only in mating type was constructed. This pair and their progeny, five alpha-type and five a type, were tested for virulence in mice. In the parent strains as well as the progeny, alpha-type was clearly more virulent than a type. In addition, death tended to occur earlier among the alpha-strain-infected mice that died than among the mice that died by infection caused by a strains. These data strongly suggest the genetic association of virulence with mating type in this human fungal pathogen.