A one pot, one step method for the preparation of clickable hydrogels by photoinitiated polymerization.
A one pot, one step method for the preparation of clickable hydrogels by photoinitiated polymerization.
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DOI：
10.1002/marc.201100470
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发表时间：
2011-12
影响因子：
4.6
通讯作者：
Gorkem Yılmaz;M. Kahveci;Y. Yagcı
中科院分区：
文献类型：
--
作者：
Gorkem Yılmaz;M. Kahveci;Y. Yagcı
目前基于水溶性单体的氧化还原或光聚合的水凝胶的制备方法使用简单且灵活，但具有需要额外的改性步骤来调整或引入用于特定目的的性质的缺点。我们设计了一种简单而快速的合成策略来制备具有反应位点的水凝胶，以通过“点击化学”掺入任何感兴趣的分子。该策略是基于在光引发聚合中使用炔丙基丙烯酰胺（PAm）作为共聚单体，与丙烯酰胺（AAm）和N，N '-亚甲基双丙烯酰胺（BAAm）一起作为交联剂。利用光化学产生的自由基对PAm的丙烯酸官能团的选择性反应性，可以一锅一步法制备具有可点击乙炔基团的水凝胶。基于乙炔官能团，任何具有叠氮基团的分子都可以通过“点击化学”缀合到水凝胶上，如荧光叠氮官能团芘的实例所示。
Current preparation methods for hydrogels based on redox or photopolymerization of water soluble monomers are simple to use, and flexible, but have the drawback of requiring additional modification steps for tuning or introducing properties for specific purposes. We have devised a simple and rapid synthetic strategy to prepare hydrogels possessing reactive sites to incorporate any molecules of interest by "Click Chemistry". The strategy is based on the use of propargyl acrylamide (PAm) as comonomer together with acrylamide (AAm) and N,N'-methylene bisacrylamide (BAAm) as crosslinker in photoinitiated polymerization. With the selective reactivity of photochemically generated free radicals towards acrylic function of PAm, hydrogels with clickable acetylene groups can be prepared in one pot, one step manner. Based on the acetylene functionality, any molecule possessing azide groups can be conjugated onto hydrogel by "Click Chemistry" as demonstrated on the example of fluoroscent azide functional pyrene.