Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease
Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease
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DOI：
10.1016/s0161-813x(02)00061-x
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发表时间：
2002-10-01
期刊：
影响因子：
3.4
通讯作者：
Checkoway, H
中科院分区：
文献类型：
--
作者：
Kelada, SN;Costa-Mallen, P;Checkoway, H
我们在一项病例对照研究中检测了吸烟与单胺氧化酶B（MAO-B）内含子13（G或A等位基因）、单胺氧化酶A（MAO-A）EcoRV（Y或N等位基因）和多巴胺D2受体（DRD 2）Taq 1 B（B1或B2等位基因）基因多态性之间的性别特异性相互作用，该研究包括186例原发性帕金森病（PD）病例和296例年龄和性别匹配的对照。曾吸烟者与从不吸烟者PD风险的比值比（OR）为0.27（95%CI：0.13-0.58），基因型G男性和1.26（0.60-2.63），基因型A男性（交互χ 2 = 8.14，P = 0.004）。而女性中GG/GA和AA基因型吸烟者与从不吸烟者的OR分别为0.62（95%CP0.25 -1.34）和20.64（95%CI：0.18-2.21）（交互作用X = 0.001，P = 0.975）。吸烟与MAO-A EcoRV或DRD 2 Taq 1B基因型之间没有相互作用。这些结果表明，一个强大的性别差异存在的修饰作用的MAO-13基因型吸烟与PD的关联。(C)2002年爱思唯尔科技有限公司All rights reserved.
We tested for gender-specific interactions between smoking and genetic polymorphisms of monoamine oxidase B (MAO-B) intron 13 (G or A allele), monoamine oxidase A (MAO-A) EcoRV (Y or N allele), and dopamine D2 recepor (DRD2) Taq1B (B1 or B2 allele) in a case-control study of 186 incident idiopathic Parkinson's disease (PD) cases and 296 age- and gender-matched controls. The odds ratios (ORs) for PD risk for ever smokers versus never smokers were 0.27 (95% CI: 0.13-0.58) for men of genotype G, and 1.26 (0.60-2.63) for men of genotype A (interaction chi(2) = 8.14, P = 0.004). In contrast, for women, the OR for ever smokers versus never smokers were 0.62 (95% CP 0.25-1.34) and 2 0.64 (95% CI: 0.18-2.21) for women of genotype GG/GA and AA, respectively (interaction X = 0.001, P = 0.975). No interactions were detected between smoking and either MAO-A EcoRV or DRD2 Taq1B genotypes. These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-13 genotype on the smoking association with PD. (C) 2002 Elsevier Science Inc. All rights reserved.