Apoptosis, complement and systemic lupus erythematosus: a mechanistic view.
Apoptosis, complement and systemic lupus erythematosus: a mechanistic view.
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细胞凋亡、补体和系统性红斑狼疮：机制观点。
DOI：
10.1159/000075687
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Ahearn,JosephM
中科院分区：
文献类型：
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作者：
Liu,Chau-Ching;Navratil,JeannineS;Sabatine,JaniceM;Ahearn,JosephM
几十年来，补体系统经典途径的缺陷一直与系统性红斑狼疮(SLE)的病因和发病机制有关。最近的进展表明，这种联系是由于补体在识别和清除细胞凋亡残留物中的关键作用。在这篇综述中，我们总结了细胞凋亡在产生自身免疫反应中的作用，并结合最近的研究进展，将细胞凋亡、补体激活与SLE的发病机制联系起来。
Deficiencies in the classical pathway of the complement system have been implicated in the etiology and pathogenesis of systemic lupus erythematosus (SLE) for several decades. Recent advances have suggested that this link is due to a critical role of complement in the recognition and clearance of the cellular remnants of apoptosis. In this review, we summarize the role of apoptosis in generation of an autoimmune response, and we integrate recent advances that link apoptosis, complement activation and the etiopathogenesis of SLE.