SEROTONIN NEURONS OF MIDBRAIN RAPHE - ASCENDING PROJECTIONS
SEROTONIN NEURONS OF MIDBRAIN RAPHE - ASCENDING PROJECTIONS
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DOI：
10.1002/cne.901800302
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发表时间：
1978-01-01
影响因子：
2.5
通讯作者：
JONES, BE
中科院分区：
文献类型：
--
作者：
MOORE, RY;HALARIS, AE;JONES, BE
使用放射自显影追踪方法分析了大鼠中脑中缝血清素神经元的上升投射。中缝血清素神经元的轴突在腹侧被盖区上升并进入内侧前脑束。许多纤维离开主要组，沿着反屈束上升。一些纤维进入缰核，但大多数在丘脑内髓层中转向，以支配背侧丘脑。另外两个较大的突出部分将内侧前脑束留在下丘脑中；脚柄腹侧杏仁束系统横向转向，穿过内囊进入纹状体复合体、杏仁核和外囊，到达外侧和后皮质，另一个纤维系统向内侧转向，支配内侧下丘脑和正中隆起，并通过视上连合形成对侧投射。在嘴侧，内侧前脑束的主要组分为几个部分：进入髓纹终止于丘脑的纤维；进入终纹的纤维终止于杏仁核；纤维穿过穹窿到达海马体；纤维穿过隔膜进入扣带回，终止于背侧皮质、内侧皮质和海马体；进入外囊的纤维支配头侧皮质和外侧皮质；纤维在内侧嗅纹中继续向前，终止于前嗅核和嗅球。
The ascending projections of serotonin neurons of the midbrain raphe were analyzed in the rat using the autoradiographic tracing method. Axons of raphe serotonin neurons ascend in the ventral tegmental area and enter the medial forebrain bundle. A number of fibers leave the major group to ascend along the fasciculus retroflexus. Some fibers enter the habenula but the majority turn rostrally in the internal medullary lamina of the thalamus to innervate dorsal thalamus. Two additional large projections leave the medial forebrain bundle in the hypothalamus; the ansa peduncularis-ventral amygdaloid bundle system turns laterally through the internal capsule into the striatal complex, amygdala and the external capsule to reach lateral and posterior cortex, and another system of fibers turns medially to innervate medial hypothalamus and median eminence and form a contralateral projection via the supraoptic commissures. Rostrally the major group in the medial forebrain bundle divides into several components: fibers entering the stria medullaris to terminate in thalamus; fibers entering the stria terminalis to terminate in the amygdala; fibers traversing the fornix to the hippocampus; fibers running through septum to enter the cingulum and terminate in dorsal and medial cortex and in hippocampus; fibers entering the external capsule to innervate rostral and lateral cortex; and fibers continuing forward in the medial olfactory stria to terminate in the anterior olfactory nucleus and olfactory bulb.