Competition controls the growth of an identified axonal arborization.
Competition controls the growth of an identified axonal arborization.
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竞争控制已确定的轴突树枝化的生长。
DOI：
10.1126/science.6729457
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Lemere,CA
中科院分区：
文献类型：
--
作者：
Murphey,RK;Lemere,CA
在已鉴定的昆虫感觉神经元中研究了轴突树枝的形状。突触前曲张在轴突内的分布受邻近终末密度的调节。切除轴突终末的一部分附近的邻居增加了失神经区域的生长速度，并在其他区域引起了代偿性回缩。结果支持轴突的大小由其内在决定，而轴突终末内的曲张分布由相邻终末的外在决定的假说。这些发现直接证明了竞争对已识别的神经细胞的影响，也是无脊椎动物中枢神经系统中竞争相互作用的首批例子之一。
The shape of the axonal arborization was studied in an identified insect sensory neuron. The distribution of presynaptic varicosities within an axonal arbor was shown to be modulated by the density of neighboring terminals. Removal of neighbors near one portion of the axon terminal increased the growth rate in the denervated region and caused a compensatory retraction in other regions. The results support the hypothesis that the size of an axonal arbor is determined intrinsically, whereas the distribution of varicosities within the terminal is determined extrinsically by neighboring terminals. These findings provide a direct demonstration of the effects of competition on an identified nerve cell, as well as one of the first examples of competitive interactions in an invertebrate central nervous system.