A poroelastic model for the perfusion of the lamina cribrosa in the optic nerve head
A poroelastic model for the perfusion of the lamina cribrosa in the optic nerve head
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DOI：
10.1016/j.mbs.2014.08.002
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发表时间：
2014-11-01
影响因子：
4.3
通讯作者：
Terragni, Samuele
中科院分区：
文献类型：
--
作者：
Causin, Paola;Guidoboni, Giovanna;Terragni, Samuele
在这项工作中，我们提出了一个数学模型的生物力学和血液动力学之间的耦合筛板，薄的多孔组织在视神经乳头的基础上，这被认为是在眼部神经退行性疾病，如青光眼的损伤部位。在这个探索性的二维研究中，筛板被建模为多孔弹性材料，其中血管被视为固体弹性基质中的孔。该模型是用来调查的应力分布的影响，血液体积分数（或血管孔隙率）和血液流速由于筛板内的应用程序的不同水平的眼内压（IOP）和不同的机械约束在椎板的边界处的执行。模型模拟表明，边界约束的固定程度强烈影响椎板对IOP升高的反应。具体而言，当边界被机械夹紧时，KW升高导致靠近椎板边界的应力增加，使其更容易受到组织损伤。另一方面，当在边界处允许旋转时，最脆弱的区域似乎位于靠近眼球地球仪的椎板的中心轴处，其中对于增加的IOP水平预测增加的应力和减少的血管孔隙度和血液速度。爱思唯尔公司出版
In this work we present a mathematical model for the coupling between biomechanics and hemodynamics in the lamina cribrosa, a thin porous tissue at the base of the optic nerve head which is thought to be the site of injury in ocular neurodegenerative diseases such as glaucoma. In this exploratory two-dimensional investigation, the lamina cribrosa is modeled as a poroelastic material where blood vessels are viewed as pores in a solid elastic matrix. The model is used to investigate the influence on the distributions of stress, blood volume fraction (or vascular porosity) and blood velocity within the lamina cribrosa due to the application of different levels of the intraocular pressure (IOP) and the enforcement of different mechanical constraints at the lamina's boundary. The model simulations suggest that the degree of fixity of the boundary constraint strongly influences the lamina's response to IOP elevation. Specifically, when the boundary is mechanically clamped, KW elevation leads to an increase in stress close to the lamina's boundary, making it more susceptible to tissue damage. On the other hand, when rotations are allowed at the boundary, the most vulnerable region appears to be located at the lamina's central axis, in proximity of the eye globe, where increased stress and reduced vascular porosity and blood velocity are predicted for increased levels of IOP. Published by Elsevier Inc.