Rhodium(II)-Catalyzed C-H Functionalization of Electron-Deficient Methyl Groups
Rhodium(II)-Catalyzed C-H Functionalization of Electron-Deficient Methyl Groups
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DOI：
10.1021/jacs.6b01941
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发表时间：
2016-05-11
影响因子：
15
通讯作者：
Davies, Huw M. L.
中科院分区：
文献类型：
--
作者：
Fu, Liangbing;Guptill, David M.;Davies, Huw M. L.
Enantioselective C-H functionalization of relatively electron-deficient methyl sites was achieved with the combination of 2,2,2-trichloroethyl aryldiazoacetates and tetralcis(triarylcyclopropanecarboxylate) dirhodium catalysts. The substrate scope of the transformation was relatively broad, and C-H functionalization products were furnished with excellent levels of enantioselectivity. As a strategic reaction, crotonate derivatives give 1,6-dicarbonyl compounds, which are useful for further diversification.
