Normal protein diet for episodic hepatic encephalopathy:: results of a randomized study
Normal protein diet for episodic hepatic encephalopathy:: results of a randomized study
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DOI：
10.1016/j.jhep.2004.03.023
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发表时间：
2004-07-01
影响因子：
25.7
通讯作者：
Guardia, J
中科院分区：
文献类型：
--
作者：
Córdoba, J;López-Hellín, J;Guardia, J
背景/目的：蛋白质限制饮食通常用于肝性脑病患者。然而，蛋白质限制可能会恶化营养状况，而不会导致肝性脑病的改善。我们设计了一项研究，以评估的影响，在饮食中的蛋白质的量的演变，情节肝性脑病。方法：肝硬化入院，因为一个事件的脑病（n = 30）被随机接受低蛋白饮食与渐进增量或正常的蛋白质饮食14天，除了标准的措施来治疗肝性脑病。蛋白质的合成和分解进行了研究，在第2天和第14天与甘氨酸-N-15输液methods.Results：肝性脑病的结果是没有显着差异，两组治疗。蛋白质的合成是相似的低蛋白和正常的蛋白质饮食，但低蛋白饮食组表现出较高的蛋白质breakdown.Conclusions：饮食与正常含量的蛋白质，这是代谢更充分，可以安全地管理到发作性肝性脑病患者。限制饮食中蛋白质的含量似乎对脑病发作期间的痴呆患者没有任何有益的影响。(C)2004年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: Protein-restricted diets are usually prescribed for cirrhotic patients with hepatic encephalopathy. However, protein restriction may worsen the nutritional status without resulting in an improvement of hepatic encephalopathy. We designed a study to assess the effects of the amount of protein in the diet on the evolution of episodic hepatic encephalopathy.Methods: Cirrhotics admitted to the hospital because of an episode of encephalopathy (n = 30) were randomized to receive a low-protein diet with progressive increments or a normal protein diet for 14 days, in addition to standard measures to treat hepatic encephalopathy. Protein synthesis and breakdown were studied at day 2 and day 14 with the glycine-N-15 infusion method.Results: The outcome of hepatic encephalopathy was not significantly different between both groups of treatment. Protein synthesis was similar for low and normal protein diet, but those of the low-protein diet group showed higher protein breakdown.Conclusions: Diets with a normal content of protein, which are metabolically more adequate, can be administered safely to cirrhotic patients with episodic hepatic encephalopathy. Restriction of the content of protein of the diet does not appear to have any beneficial effect for cirrhotic patients during an episode of encephalopathy. (C) 2004 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.