Carboxylation of C-H Bonds Using N-Heterocyclic Carbene Gold(I) Complexes
Carboxylation of C-H Bonds Using N-Heterocyclic Carbene Gold(I) Complexes
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DOI：
10.1021/ja103429q
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发表时间：
2010-07-07
影响因子：
15
通讯作者：
Nolan, Steven P.
中科院分区：
文献类型：
--
作者：
Boogaerts, Ine I. F.;Nolan, Steven P.
建立了一种高效的[(NHC)Au-1]基（NHC = n -杂环碳烯）催化体系，用于芳香和杂芳香C-H键的羧化反应。Au-OH的显著碱强度是激活过程的起源，并允许C-H键的容易功能化，而无需使用其他有机金属试剂。
A highly efficient [(NHC)Au-1]-based (NHC = N-heterocyclic carbene) catalytic system for the carboxylation of aromatic and heteroaromatic C-H bonds was developed. The significant base strength of the Au-OH species is at the origin of the activation process and permits the facile functionalization of C-H bonds without the use of other organometallic reagents.