Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.
Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.
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DOI：
10.1155/2008/864140
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发表时间：
2008
期刊：
影响因子：
2.9
通讯作者：
Minghetti L
中科院分区：
文献类型：
--
作者：
Bernardo A;Minghetti L
近年来，过氧化物酶体增殖物激活受体-γ（peroxisome proliferator-activated receptor-γ，PPAR-γ）作为II型糖尿病治疗的靶点，因其在炎症和退行性脑疾病中的治疗潜力而受到越来越多的关注。PPAR-γ激动剂，其包括天然存在的化合物（例如长链脂肪酸和环戊烯酮前列腺素15-脱氧Δ 12，14前列腺素J2），和合成激动剂（其中噻唑烷二酮类和少数非甾体抗炎药）在阿尔茨海默病和帕金森病、肌萎缩性侧索硬化、多发性硬化症和中风，以及一些临床研究。PPAR-γ激动剂的多效性作用可能由几种机制介导，包括对外周免疫细胞（巨噬细胞和淋巴细胞）的抗炎活性，以及对神经细胞（包括脑血管内皮细胞、神经元和神经胶质）的直接作用。在这篇文章中，我们将回顾最近的研究结果，支持的主要作用，过氧化物酶体增殖物激活受体-γ激动剂在控制神经炎症和神经变性，通过其对胶质细胞的活动，特别强调小胶质细胞作为主要的巨噬细胞群体的脑实质和主要演员在脑炎症。
In the recent years, the peroxisome proliferator-activated receptor-γ (PPAR-γ), a well known target for type II diabetes treatment, has received an increasing attention for its therapeutic potential in inflammatory and degenerative brain disorders. PPAR-γ agonists, which include naturally occurring compounds (such as long chain fatty acids and the cyclopentenone prostaglandin 15-deoxy Δ12,14 prostaglandin J2), and synthetic agonists (among which the thiazolidinediones and few nonsteroidal anti-inflammatory drugs) have shown anti-inflammatory and protective effects in several experimental models of Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, multiple sclerosis and stroke, as well as in few clinical studies. The pleiotropic effects of PPAR-γ agonists are likely to be mediated by several mechanisms involving anti-inflammatory activities on peripheral immune cells (macrophages and lymphocytes), as well as direct effects on neural cells including cerebral vascular endothelial cells, neurons, and glia. In the present article, we will review the recent findings supporting a major role for PPAR-γ agonists in controlling neuroinflammation and neurodegeneration through their activities on glial cells, with a particular emphasis on microglial cells as major macrophage population of the brain parenchyma and main actors in brain inflammation.
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影响因子：
5.3
作者：
Combs, CK;Johnson, DE;Landreth, GE
通讯作者：
Landreth, GE
DOI：
10.1093/jnen/62.5.509
发表时间：
2003-05-01
影响因子：
3.2
作者：
Bernardo, A;Greco, A;Minghetti, L
通讯作者：
Minghetti, L
影响因子：
168.9
作者：
Dormandy, JA;Charbonnel, B;Taton, J
通讯作者：
Taton, J
影响因子：
4.7
作者：
Bernardo, A;Ajmone-Cat, MA;Minghetti, L
通讯作者：
Minghetti, L
影响因子：
3.4
作者：
Bernardo, A;Levi, G;Minghetti, L
通讯作者：
Minghetti, L