Efficient penetration into aqueous humor by administration of oral and topical levofloxacin.
Efficient penetration into aqueous humor by administration of oral and topical levofloxacin.
复制标题
通过口服和局部左氧氟沙星有效渗透到房水中。
DOI：
10.1089/jop.2011.0006
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
M. Zako
中科院分区：
文献类型：
--
作者：
M. Ishida;Takuya Kataoka;K. Niwa;M. Iwaki;M. Zako
目的
我们研究了口服和局部左氧氟沙星的优化组合是否会导致更高的左氧氟沙星在房水中的浓度。
方法
15例双眼白内障患者在首次手术前1周开始局部治疗，在首次手术前1天开始口服治疗。在手术当天，他们分别在术前4 h和1 h口服和外用左氧氟沙星。第一次手术后两天，我们用相同的药物给药方案对第二只眼睛进行白内障手术。
结果
术后第1眼和第2眼房水中左氧氟沙星浓度分别为2.87±0.89 μg/mL（均数±标准差，n=15）和3.76±1.32 μg/mL，第2眼的左氧氟沙星浓度显著高于第1眼（P=0.0085）。
结论
我们的方案，以实现高浓度的左氧氟沙星的房水可能有利于预防眼手术后眼内炎。
PURPOSE
We investigated whether an optimized combination of oral and topical levofloxacin would lead to higher levofloxacin concentrations in aqueous humor.
METHODS
Fifteen patients with cataracts in both eyes began topical treatment at 1 week before the first surgery and oral treatment at 1 day before the first surgery. On the day of surgery, they received oral and topical levofloxacin at 4 h and 1 h before surgery, respectively. Two days after the first operation, we performed cataract surgery on the second eye with the same drug administration protocol.
RESULTS
Postsurgery concentrations of levofloxacin in the aqueous humor of the first and second eyes were 2.87±0.89 μg/mL (mean±standard deviation, n=15) and 3.76±1.32 μg/mL, respectively; the levofloxacin level in the second eye was significantly higher than that in the first eye (P=0.0085).
CONCLUSIONS
Our protocol to achieve high aqueous humor concentrations of levofloxacin may be favorable in preventing endophthalmitis after eye surgery.