Synthesis of biodegradable high molecular weight polycarbonates from 1,3‐trimethylene carbonate and 2,2‐dimethyltrimethylene carbonate
Synthesis of biodegradable high molecular weight polycarbonates from 1,3‐trimethylene carbonate and 2,2‐dimethyltrimethylene carbonate
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DOI：
10.1002/app.40037
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发表时间：
2014-03
影响因子：
3
通讯作者：
Małgorzata Pastusiak;P. Dobrzyński;J. Kasperczyk;A. Smola;H. Janeczek
中科院分区：
文献类型：
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作者：
Małgorzata Pastusiak;P. Dobrzyński;J. Kasperczyk;A. Smola;H. Janeczek
提出了以碳酸三亚甲基酯（TMC）和2，2-二甲基碳酸三亚甲基酯（DTC）为单体，通过设计共聚单元组成，合成可生物降解的高分子量脂肪族聚碳酸酯的可能性。乙酰丙酮锌（II）一水合物用作催化剂。通过高分辨率13 C-NMR光谱进行共聚物链结构的详细分析。给出了共聚物链段平均长度、无规化系数和酯交换系数等特征参数的计算公式。测定了共聚竞聚率（rTMC = 1.17 ± 0.20和rDTC= 0.42 ± 0.09）。共聚单体反应活性的显著差异和低酯交换导致梯度链微观结构。合成的共聚物含有约80mol%的DTC单元，是一种具有良好机械性能的半结晶材料，允许将该材料应用于形成生物可吸收的柔性植入物或支架。© 2013威利期刊公司. J.应用聚合物科学，2014，131，40037。
The possibility to obtain biodegradable high molecular weight aliphatic polycarbonates from trimethylene carbonate (TMC) and 2,2-dimethyltrimethylene carbonate (DTC) monomers with designed composition of comonomeric units was presented. Zinc(II) acetylacetonate monohydrate was used as a catalyst. A detailed analysis of copolymer chain structure was performed by means of high resolution 13C-NMR spectroscopy. The equations for calculation of characteristic parameters of copolymer chain such as average length of blocks, randomization and transesterification coefficients were shown. The copolymerization reactivity ratios were determined (rTMC = 1.17 ± 0.20 and rDTC= 0.42 ± 0.09). Significant differences in the reactivity of comonomers and the low transesterification result in gradient chain microstructure. The synthesized copolymer containing about 80 mol % of DTC units is a semicrystalline material with good mechanical properties, allowing for application of this material in the formation of bioresorbable flexible implants or scaffolds. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2014, 131, 40037.