Impact of anesthesia on echocardiographic evaluation of systolic and diastolic function in rats
Impact of anesthesia on echocardiographic evaluation of systolic and diastolic function in rats
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DOI：
10.1016/j.echo.2006.06.011
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发表时间：
2006-12-01
影响因子：
6.5
通讯作者：
Couet, Jacques
中科院分区：
文献类型：
--
作者：
Plante, Eric;Lachance, Dominic;Couet, Jacques
背景：超声心动图用于大鼠，但通常需要全身麻醉才能获得高质量的超声心动图。每种类型的麻醉剂对血流动力学都有特定的影响，因此可能对超声心动图测量产生不同的影响。目的：我们试图比较正常大鼠和慢性主动脉瓣反流大鼠在使用氯胺酮-甲苯噻嗪或异氟醚麻醉下的超声心动图。方法。动物依次接受两种药物的超声心动图检查。比较超声心动图测量结果。正常组中二尖瓣舒张期多普勒测量（舒张早期充盈波 [E] 和心房舒张晚期充盈波 [A] 速度）显着受麻醉类型影响，但左心室尺寸或射血分数不受影响。主动脉瓣反流组的左心室尺寸受到麻醉类型和舒张期多普勒血流的影响。结论：麻醉剂对许多超声心动图测量有显着的特异性影响。研究大鼠模型的研究人员应该意识到这些潜在的影响。
Background: Echocardiography is used on rats but general anesthesia is usually necessary to be able to obtain a good quality echocardiogram. Each type of anesthetic agent has specific impacts on hemodynamics and, therefore, may affect differentially the echocardiographic measurements.Objectives: We sought to compare the echocardiograms of normal rats and rats with chronic aortic regurgitation under anesthesia using ketamine-xylazine or isoflurane.Methods. Animals underwent an echocardiogram with both drugs sequentially. Echocardiographic measurements were compared.Results. Mitral diastolic Doppler measurements (early diastolic filling wave [E] and late atrial diastolic filling wave [A] velocities) were significantly affected by the type of anesthesia in the normal group but not left ventricular dimensions or ejection fraction. Left ventricular dimensions were affected by the type of anesthesia in the aortic regurgitation group and diastolic Doppler flow.Conclusion: The anesthetic agent has significant specific impacts on many echocardiographic measurements. Investigators working with rat models should be aware of those potential effects.