Time and space are complementary encoding dimensions in the moth antennal lobe
Time and space are complementary encoding dimensions in the moth antennal lobe
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DOI：
10.1080/09548980701242573
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发表时间：
2007-03-01
影响因子：
7.8
通讯作者：
Verschure, Paul F. M. J.
中科院分区：
文献类型：
--
作者：
Knuesel, Philipp;Carlsson, Mikael A.;Verschure, Paul F. M. J.
时间对神经系统信息编码的贡献仍然存在争议。嗅觉系统是对这个问题进行实证研究的标准制剂之一。例如，触角叶或嗅球的输出神经元显示出气味刺激引起的其放电速率的时间调制，幅度为数百毫秒。然而，这些时间模式在气味刺激编码中的作用尚不清楚。在这里，我们使用蛾触角叶投射神经元的光学成像来解决这个问题。首先，我们提出了一个生物物理衍生模型，可以准确描述投射神经元的钙反应。基于该模型，我们随后表明投射神经元的钙反应显示出刺激特定的时间结构。最后，我们证明，与纯粹的空间编码相比，包含此时间信息的编码方案可将分类性能提高 60%。尽管组合时空编码策略的假定作用一直是争论的主题，但我们的结果首次定量地证实昆虫大脑使用了这种编码策略。
The contribution of time to the encoding of information by the nervous system is still controversial. The olfactory system is one of the standard preparations where this issue is empirically investigated. For instance, output neurons of the antennal lobe or the olfactory bulb display odor stimulus induced temporal modulations of their firing rate at a scale of hundreds of milliseconds. The role of these temporal patterns in die encoding of odor stimuli, however, is not yet known. Here, we use optical imaging of the projection neurons of the moth antennal lobe to address this question. First, we present a biophysically derived model that provides an accurate description of the calcium response of projection neurons. On the basis of this model, we subsequently show that the calcium response of the projection neurons displays a stimulus specific temporal structure. Finally, we demonstrate that an encoding scheme that includes this temporal information boosts classification performance by 60% as compared to a purely spatial encoding. Although the putative role of combinatorial spatio-temporal encoding strategies has been the subject of debate, our results for the first time establish quantitatively that such an encoding strategy is used by the insect brain.