Decarboxylative Coupling of -Keto Acids with ortho-Phenylenediamines Promoted by an Electrochemical Method in Aqueous Media
Decarboxylative Coupling of -Keto Acids with ortho-Phenylenediamines Promoted by an Electrochemical Method in Aqueous Media
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水介质中电化学方法促进酮酸与邻苯二胺的脱羧偶联
DOI：
10.1002/adsc.201501167
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发表时间：
2016
影响因子：
5.4
通讯作者：
Jing-Mei Huang
中科院分区：
文献类型：
--
作者：
Hai-Bin Wang;Jing-Mei Huang
建立了α-酮酸与邻苯二胺脱羧偶联的电化学方法。反应在无空气和金属催化剂的条件下在水溶液中顺利进行，以良好的产率得到2-取代的苯并咪唑。苯并噻唑也可以通过该方案合成。
An electrochemical method for the decarboxylative coupling ofα‐keto acids withortho‐phenylenediamines was developed. The reaction proceeded smoothly in aqueous solution under air and metal catalyst‐free conditions to afford 2‐substituted benzimidazoles in good yields. Benzothiazoles could also be synthesized by this protocol.