Identification of separable cognitive factors in schizophrenia
Identification of separable cognitive factors in schizophrenia
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DOI：
10.1016/j.schres.2004.09.007
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发表时间：
2004-12-15
影响因子：
4.5
通讯作者：
Heaton, RK
中科院分区：
文献类型：
--
作者：
Nuechterlein, KH;Barch, DM;Heaton, RK
NIMH倡议的主要目标之一是鼓励开发针对精神分裂症认知缺陷的新干预措施，即改善精神分裂症认知的测量和治疗研究（matrix），旨在开发一种可靠有效的共识认知电池，用于临床试验。缺乏这样一组药物阻碍了对新疗法的标准化评估，在药理学方面，也阻碍了FDA批准针对精神分裂症认知缺陷的药物。开发这种电池的一个基本步骤是确定精神分裂症中主要的可分离的认知障碍。作为这项工作的一部分，我们评估了精神分裂症认知表现维度的经验证据，强调因素分析研究。我们的结论是，七个可分离的认知因素在研究中是可复制的，它们代表了精神分裂症认知缺陷的基本维度：加工速度、注意/警惕性、工作记忆、言语学习和记忆、视觉学习和记忆、推理和解决问题以及言语理解。由于最近对该领域的兴趣增加，以及其他与临床试验相关的证据，增加了第八个领域，社会认知，旨在评估潜在的认知增强剂对认知表现和功能结果的影响。言语理解被认为不适合对认知变化敏感的认知电池，因为它对变化的抵抗。其余7个领域被建议纳入matrix - nimh共识认知电池，并将作为该电池的基本结构。这些可分离的认知维度也与未来旨在理解精神分裂症核心认知缺陷的性质和结构的研究具有更广泛的相关性。(C) 2004 Elsevier B.V.版权所有
One of the primary goals in the NIMH initiative to encourage development of new interventions for cognitive deficits in schizophrenia, Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS), has been to develop a reliable and valid consensus cognitive battery for use in clinical trials. Absence of such a battery has hampered standardized evaluation of new treatments and, in the case of pharmacological agents, has been an obstacle to FDA approval of medications targeting cognitive deficits in schizophrenia. A fundamental step in developing such a battery was to identify the major separable cognitive impairments in schizophrenia. As part of this effort, we evaluated the empirical evidence for cognitive performance dimensions in schizophrenia, emphasizing factor analytic studies. We concluded that seven separable cognitive factors were replicable across studies and represent fundamental dimensions of cognitive deficit in schizophrenia: Speed of Processing, Attention/Vigilance, Working Memory, Verbal Learning and Memory, Visual Learning and Memory, Reasoning and Problem Solving, and Verbal Comprehension. An eighth domain, Social Cognition, was added due to recent increased interest in this area and other evidence of its relevance for clinical trials aiming to evaluate the impact of potential cognitive enhancers on cognitive performance and functional outcome. Verbal Comprehension was not considered appropriate for a cognitive battery intended to be sensitive to cognitive change, due to its resistance to change. The remaining seven domains were recommended for inclusion in the MATRICS-NIMH consensus cognitive battery and will serve as the basic structure for that battery. These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia. (C) 2004 Elsevier B.V. All rights reserved.