Network Interconnectivity and Community Detection in HIV/Syphilis Contact Networks Among Men Who Have Sex With Men.
Network Interconnectivity and Community Detection in HIV/Syphilis Contact Networks Among Men Who Have Sex With Men.
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DOI：
10.1097/olq.0000000000001250
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发表时间：
2020-11
影响因子：
3.1
通讯作者：
Powers KA
中科院分区：
文献类型：
--
作者：
Billock RM;Mucha PJ;Samoff E;Dennis AM;Pence BW;Lund JL;Powers KA
尽管艾滋病毒和梅毒在男男性行为者（MSM）中持续流行，但艾滋病毒和梅毒接触网络之间的关系尚未得到很好的表征。我们的目的是衡量艾滋病毒和梅毒接触网络之间的相互联系，男男性接触者和确定网络社区与艾滋病毒网络的梅毒网络的相互联系。使用接触者追踪数据，我们为2015年至2017年期间北卡罗来纳州诊断为艾滋病毒或早期梅毒的所有MSM分别生成了独立和合并的艾滋病毒和梅毒网络。我们将独立网络视为层，并在双层网络中识别网络社区或密集连接的节点组。我们通过比较梅毒网络中梅毒网络成员之间的平均节点度来评估互连性。梅毒网络与艾滋病毒网络相互关联，特别是在中位年龄较低的网络社区，自我认定为黑人，非西班牙裔的比例较高，以及在性传播疾病诊所诊断的梅毒病例比例较高。相互联系的接触网络是男男性行为者，特别是年轻的黑人男男性行为者艾滋病毒和梅毒流行的基础。在高度互联的网络社区内加强传播预防干预可能特别有益。一项关于性接触追踪网络的研究发现，艾滋病毒和梅毒网络在男男性行为者（MSM）中相互关联，特别是在年轻的黑人男男性行为者中。
Despite persistent HIV and syphilis epidemics among men who have sex with men (MSM), the relationship between HIV and syphilis contact networks has not been well characterized. We aimed to measure interconnectivity between HIV and syphilis contact networks among MSM and identify network communities with heightened interconnectivity of the syphilis network with the HIV network. Using contact tracing data, we generated independent and combined HIV and syphilis networks for all MSM diagnosed with HIV or early syphilis, respectively, in North Carolina between 2015 and 2017. We treated the independent networks as layers and identified network communities, or groups of densely connected nodes, in the two-layer network. We assessed interconnectivity by comparing the mean node degree among syphilis network members in the syphilis network alone vs. the combined HIV/syphilis network, both overall and by network community. The syphilis network was interconnected with the HIV network, especially in network communities with younger median age, higher proportions of persons self-identifying as Black, non-Hispanic, and higher proportions of syphilis cases diagnosed at sexually transmitted disease clinics. Interconnected contact networks underlie HIV and syphilis epidemics among MSM, particularly among young, Black MSM. Intensified transmission prevention interventions within highly interconnected network communities may be particularly beneficial. A study of sexual contact tracing networks found that HIV and syphilis networks are interconnected among men who have sex with men (MSM), particularly among young, Black MSM.