BCL-2 PROTEIN IN NON-SMALL-CELL LUNG-CARCINOMA
BCL-2 PROTEIN IN NON-SMALL-CELL LUNG-CARCINOMA
复制标题
DOI：
10.1056/nejm199309023291003
复制
发表时间：
1993-09-02
影响因子：
158.5
通讯作者：
MASON, DY
中科院分区：
文献类型：
--
作者：
PEZZELLA, F;TURLEY, H;MASON, DY
背景原癌基因bcl-2编码抑制程序性细胞死亡（凋亡）的蛋白质。该蛋白在正常人上皮的基底细胞中表达，但没有关于其在癌中表达的频率或临床重要性的数据。我们研究了bcl-2在非小细胞肺癌患者中的表达，并将这种现象与生存率相关。用抗bcl-2单克隆抗体进行免疫化学分析，检测122例鳞状细胞癌（80例）或腺癌（42例）手术患者肿瘤标本中的蛋白质。采用对数秩检验、风险比及其置信区间研究bcl-2表达与生存率相关的可能性。我们在25%的鳞状细胞癌（80例中的20例）和12%的腺癌（42例中的5例）中检测到bcl-2蛋白。在相邻的正常呼吸道上皮中，bcl-2仅在基底细胞中表达。bcl-2阳性肿瘤患者的5年生存率较高（P
Background. The proto-oncogene bcl-2 encodes a protein that inhibits programmed cell death (apoptosis). The protein is expressed in basal cells in normal human epithelium, but no data are available on the frequency or clinical importance of its expression in carcinoma. We studied bcl-2 expression in patients with non-small-cell lung carcinoma and correlated this phenomenon with survival.Methods. Immunochemical analysis with a monoclonal antibody specific for bcl-2 was used to detect the protein in tumor samples from 122 patients undergoing surgery for squamous-cell carcinoma (80 patients) or adenocarcinoma (42 patients). The possibility that bcl-2 expression correlated with survival was investigated with use of the log-rank test, hazard ratios, and their confidence intervals.Results. We detected bcl-2 protein in 25 percent of squamous-cell carcinomas (20 of 80) and 12 percent of adenocarcinomas (5 of 42). In adjacent normal respiratory epithelium, bcl-2 was expressed only in basal cells. Survival at five years was higher among patients with bcl-2-positive tumors, both in the group as a whole (P