Simultaneous separation of sixteen positional and optical isomers of the tryptophan family by ligand-exchange micellar electrokinetic chromatography
Simultaneous separation of sixteen positional and optical isomers of the tryptophan family by ligand-exchange micellar electrokinetic chromatography
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通过配体交换胶束电动色谱同时分离色氨酸家族的十六种位置异构体和旋光异构体
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
T. Hobo
中科院分区：
文献类型：
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作者：
Zilin Chen;Jin;K. Uchiyama;T. Hobo
摘要用配体交换胶束电动色谱法同时分离色氨酸家族的16个位置和光学异构体。以L-羟脯氨酸与铜(II)形成的络合物作为手性选择剂。采用直链烷基苯磺酸盐(LAS)和直链烷基硫酸盐(SDES)、十二烷基硫酸钠(SDS)和十四烷基硫酸钠(STS)两类阴离子表面活性剂同时分离。结果表明，采用十二烷基硫酸钠的效果最好。考察了十二烷基硫酸钠浓度和pH对分离的影响。研究了在没有L-羟脯氨酸铜(II)络合物存在的情况下的分离行为。使用有机改性剂会导致分辨率降低。讨论了辛醇-水分配系数(LogPOW)的对数与分离度的关系，以及logPOW与迁移时间的关系。
SummaryLigand-exchange micellar electrokinetic chromatography has been used for the simultaneous separation of 16 positional and optical isomers of the tryptophan family. The Cu(II) complex with L-hydroxyproline was used as the chiral selector. Two groups of anionic surfactant, linear alkylbenzenesulfonates (LAS) and straight-chain alkyl sulfates such as sodiumn-decyl sulfate (SDeS), sodium dodecyl sulfate (SDS) and sodiumn-tetradecyl sulfate (STS), were used for simultaneous separation. The best result was obtained by use of SDS. The influence of SDS concentration and of pH on the separation was investigated. The separation behavior in the absence of the Cu(II) complex with L-hydroxyproline was also examined. Use of organic modifiers causes the resolution to decrease. Relationships between the logarithm of the octanol-water partition coefficient (logPOW) and resolution, and between logPOW and migration time are discussed.
胶束电动色谱中的化学选择性：溶质-胶束相互作用的表征，用于表面活性剂的分类。
影响因子：
7.4
作者：
Yang,S;Khaledi,MG
通讯作者：
Khaledi,MG