A CONVENIENT SYNTHESIS OF CYCLIC-PEPTIDES AS REGIOSELECTIVELY ADDRESSABLE FUNCTIONALIZED TEMPLATES (RAFT)
A CONVENIENT SYNTHESIS OF CYCLIC-PEPTIDES AS REGIOSELECTIVELY ADDRESSABLE FUNCTIONALIZED TEMPLATES (RAFT)
复制标题
DOI：
10.1016/0040-4039(94)02481-p
复制
发表时间：
1995-02-20
影响因子：
1.8
通讯作者：
MUTTER, M
中科院分区：
文献类型：
--
作者：
DUMY, P;EGGLESTON, IM;MUTTER, M
含有多达四个正交保护赖氨酸残基的环状十肽已被有效地制备相结合的固相和溶液的策略。这些环肽代表了新的区域选择性寻址功能化模板（RAFT），适用于根据TASP概念进行蛋白质从头设计。
Cyclic decapeptides containing up to four orthogonally protected lysine residues have been efficiently prepared by a combined solid phase and solution strategy. These cyclic peptides represent new Regioselectively Addressable Functionalized Templates (RAFT), which are suitable for use in protein de novo design according to the TASP concept.