Autonomic nerve tumour with skeinoid fibres: ultrastructure of skeinoid fibres examined by quick-freezing and deep-etching method
Autonomic nerve tumour with skeinoid fibres: ultrastructure of skeinoid fibres examined by quick-freezing and deep-etching method
复制标题
具有束状纤维的自主神经肿瘤：速冻深蚀法检测束状纤维超微结构
作者：
A. Hemmi;A. Komiyama;S. Ohno;Y. Fujii;N. Terada;R. Katoh,;A. Yokoyama;A. Kawaoi
摘要采用速冻深度刻蚀法（QF-DE）对79岁日本男性空肠伴skeinoid纤维（SFs）的胃肠道自主神经肿瘤进行了检查。肿瘤由梭形细胞组成，对vimentin、NSE和CD34有免疫组化反应。电镜下观察了肌肠丛神经细胞的特征。QF-DE方法显示细胞间网状结构，由细丝（7-15 nm）组成，具有颗粒沉积物。沉积物完全发育的部分形成由表面不规则的粗原纤维（30-48 nm）组成的结节状聚集体，并倾向于线性排列（sf）。我们在SFs之间检测到许多相互连接的细丝（ICTFs），这些细丝是网络中预先存在的成分，避免了颗粒沉积。由SFs和ictf之间的连接形成的焦点增厚显示了典型的SFs （33-45 nm）的周期性。我们得出结论，SFs是由颗粒沉积物沿着预先存在的细胞间网络结构进行装饰而形成的。
Abstract A case of gastrointestinal autonomic nerve tumour with skeinoid fibres (SFs) of the jejunum in a 79-year-old Japanese man, was examined by the quick-freezing and deep-etching (QF-DE) method. The tumour consisted of spindle cells with immunohistochemical reactions for vimentin, NSE and CD34. Electron microscopically, features of the neural cells of the myenteric plexus were observed. The QF-DE method demonstrated intercellular meshwork structures, consisting of thin filaments (7–15 nm), with granular deposits. Fully developed parts of the deposits formed nodular aggregates composed of irregularly surfaced thick fibrils (30–48 nm) with a tendency to linear arrangement (SFs). We detected many interconnecting thin filaments (ICTFs) between the SFs, which were pre-existing components in the meshwork, avoiding the granular deposits. The focal thickening formed by the connection between SFs and ICTFs revealed a periodicity typical of SFs (33–45 nm). We conclude that SFs are formed by decoration of the granular deposits along pre-existing intercellular meshwork structures.
胃肠道自主神经（GAN）肿瘤。
影响因子：
4.6
作者：
Walker,P;Dvorak,AM
通讯作者：
Dvorak,AM