Evidence for de novo evolution of testis-expressed genes in the Drosophila yakuba Drosophila erecta clade
Evidence for de novo evolution of testis-expressed genes in the Drosophila yakuba Drosophila erecta clade
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DOI：
10.1534/genetics.106.069245
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发表时间：
2007-06-01
期刊：
影响因子：
3.3
通讯作者：
Jones, Corbin D.
中科院分区：
文献类型：
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作者：
Begun, David J.;Lindfors, Heather A.;Jones, Corbin D.
新基因的突变起源和随后的进化，被假设为最近起源的基因，与祖先的编码序列没有明显的关系，知之甚少。然而，越来越多的证据表明，这些基因可能经常在男性生殖中发挥作用。在这里，我们使用来自果蝇睾丸的表达序列标签（ESTs）来鉴定可能出现在D。yakuba或D. yakuba D.直立祖先我们发现了几个这样的基因，它们表现出睾丸偏好的表达，并且通常是X连锁的。比较数据表明，这些基因中有三个具有非常短的开放阅读框架，这表明在D. yakuba D.直立进化枝可能是非编码RNA基因。这些数据，沿着与以前公布的数据从D。Melanogaster等的研究结果支持了果蝇中许多新基因在雄性生殖中起作用的观点，并且支持了果蝇亚群中X染色体的一个小区域可能是新睾丸偏向基因进化的热点。
The mutational origin and subsequent evolution of de novo genes, which are hypothesized to be genes of recent origin that are not obviously related to ancestral coding sequence, are poorly understood. However, accumulating evidence Suggests that such genes may often function in male reproduction. Here we use testis-derived expressed sequence tags (ESTs) from Drosophila yakuba-ttoidentify genes that have likely arisen either in D. yakuba or in the D. yakuba/ D. erecta ancestor. We found several such genes, which show testis-biased expression and are often X-linked. Comparative data indicate that three of these genes have very short open reading frames, which suggests the possibility that a significant number of testis-biased de novo genes in the D. yakuba/ D. erecta clade may be noncoding RNA genes. These data, along with previously published data from D. melanogaster, support the idea that many de novo Drosophila genes function in male reproduction and that a small region of the X chromosome in the)melanogaster subgroup may be a hotspot for the evolution of novel testis-biased genes.