The immune response of healthy adults to a reduced dose of hepatitis B vaccine
The immune response of healthy adults to a reduced dose of hepatitis B vaccine
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DOI：
10.1002/jmv.1890080206
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发表时间：
1981
影响因子：
12.7
通讯作者：
W. Szmuness;W. Szmuness;C. Stevens;E. Harley;Edith Zang;P. Taylor;H. Alter
中科院分区：
文献类型：
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作者：
W. Szmuness;W. Szmuness;C. Stevens;E. Harley;Edith Zang;P. Taylor;H. Alter
来自血液透析中心的336名医务人员接受了3剂默克B型肝炎疫苗（0、1和6个月）治疗，每剂20 μg。在第一次注射后1个月内，41%转化为抗-HBs阳性;在第二次注射后，转化率上升到80-90%;在加强注射后，达到96- 98%。在18个月随访期间，晚期发生率保持不变。只有2.8%的接种者对疫苗没有反应。发现20 μg剂量的免疫应答模式与40 μg剂量完全相同。有人建议，减少剂量的疫苗应该是有效的，因为大的。
Three hundred thirty‐six medical personnel from hemodialysis centers were treated with three doses, 20 μg each, of the Merck hepatitis B vaccine (at 0, 1, and 6 months). Within 1 month after the first injection, 41% converted to anti‐HBs positivity; after the second injection the conversion rate rose to 80–90%; and after the booster, to 96–98%. The later rate remained unchanged during the 18‐month follow‐up period. Only 2.8% of those vaccinated did not respond to the vaccine. The patterns of immune responses to 20‐μg doses were found to be exactly the same as to 40‐μg doses. It is suggested that reduced doses of vaccine should be as efficacious as the larger ones.