Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER.
Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER.
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DOI：
10.1016/j.eplepsyres.2014.09.016
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发表时间：
2014-12
影响因子：
2.2
通讯作者：
Warfield SK
中科院分区：
文献类型：
--
作者：
Suarez RO;Taimouri V;Boyer K;Vega C;Rotenberg A;Madsen JR;Loddenkemper T;Duffy FH;Prabhu SP;Warfield SK
在这项研究中，我们验证了为临床应用而设计的被动语言功能磁共振成像方案在儿科癫痫手术计划中的应用，因为它们不需要患者的公开参与。我们引入了一套质量检查来评估用于临床目的的非侵入性功能磁共振成像的可靠性。我们最初比较了两种fMRI语言映射范例，一种是主动的(需要患者参与)，另一种是被动的(不需要患者的参与)。在健康对照队列中的群体水平分析显示，大脑的下额叶(IFG)和颞顶(TPG)区域的假定语言中心类似地激活。此外，我们还发现，与主动任务相比，被动语言fMRI在TPG(LI=+0.45)中产生了更多的左侧化激活；同样，使用被动任务时，左侧化IFG(LI=+0.24)的激活也同样强健。通过与侵袭性临床金标准的直接比较，我们在15名儿童癫痫患者队列中验证了我们推荐的fMRI标测方案。我们发现，在同一患者中，fMRI的语言特异性TPG激活与有创功能标测的硬膜下定位在9.2 mm以内一致，fMRI的语言优势与Wada测试结果一致，TPG的符合率为80%，IFG的符合率为73%。最后，我们在一组非常年轻的患者中测试了推荐的被动语言功能磁共振成像方案，并在这个具有挑战性的队列中确认了可靠的特定语言激活模式。我们的结论是，即使在非常年轻(平均7.5岁)或服用镇静剂的儿童癫痫患者中，使用我们提出的被动语言功能磁共振成像方案也可以可靠地获得语言激活图。
In this study we validate passive language fMRI protocols designed for clinical application in pediatric epilepsy surgical planning as they do not require overt participation from patients. We introduced a set of quality checks that assess reliability of noninvasive fMRI mappings utilized for clinical purposes. We initially compared two fMRI language mapping paradigms, one active in nature (requiring participation from the patient) and the other passive in nature (requiring no participation from the patient). Group-level analysis in a healthy control cohort demonstrated similar activation of the putative language centers of the brain in the inferior frontal (IFG) and temporoparietal (TPG) regions. Additionally, we showed that passive language fMRI produced more left-lateralized activation in TPG (LI = +0.45) compared to the active task; with similarly robust left-lateralized IFG (LI = +0.24) activations using the passive task. We validated our recommended fMRI mapping protocols in a cohort of 15 pediatric epilepsy patients by direct comparison against the invasive clinical gold-standards. We found that language-specific TPG activation by fMRI agreed to within 9.2 mm to subdural localizations by invasive functional mapping in the same patients, and language dominance by fMRI agreed with Wada test results at 80% congruency in TPG and 73% congruency in IFG. Lastly, we tested the recommended passive language fMRI protocols in a cohort of very young patients and confirmed reliable language-specific activation patterns in that challenging cohort. We concluded that language activation maps can be reliably achieved using the passive language fMRI protocols we proposed even in very young (average 7.5 years old) or sedated pediatric epilepsy patients.
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影响因子：
10.6
作者：
Grau, V;Mewes, AUJ;Warfield, SK
通讯作者：
Warfield, SK
影响因子：
5.7
作者：
Branco, Daniel M.;Suarez, Ralph O.;Golby, Alexandra J.
通讯作者：
Golby, Alexandra J.
影响因子：
2.6
作者：
Duffy, Frank H.;Eksioglu, Yaman Z.;Als, Heidelise
通讯作者：
Als, Heidelise
影响因子：
5.7
作者：
Birn, RM;Cox, RW;Bandettini, PA
通讯作者：
Bandettini, PA
影响因子：
2.6
作者：
Sharan, Ashwini;Ooi, Yinn Cher;Sperling, Michael R.
通讯作者：
Sperling, Michael R.