CONTINUOUS INVIVO MONITORING OF ARTERIAL OXYGENATION IN CHRONIC OBSTRUCTIVE LUNG-DISEASE
CONTINUOUS INVIVO MONITORING OF ARTERIAL OXYGENATION IN CHRONIC OBSTRUCTIVE LUNG-DISEASE
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DOI：
10.7326/0003-4819-86-6-725
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发表时间：
1977-01-01
影响因子：
39.2
通讯作者：
BLOCK, AJ
中科院分区：
文献类型：
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作者：
FLICK, MR;BLOCK, AJ
10例严重慢性阻塞性肺疾病患者在24小时呼吸室内空气，然后24小时呼吸2升O2/min的动脉血氧饱和度（SaO 2）进行监测。3名无慢性阻塞性肺疾病的受试者在呼吸室内空气时进行监测。SaO 2的最大下降发生在睡眠期间，间歇性下降高达44%饱和度（范围，12%-44%饱和度）。当患者呼吸低流量O2时，基线SaO 2显著更高（94% vs. 86%饱和），睡眠期间SaO 2下降不太明显（1%-27%饱和）。无慢性阻塞性肺病的受试者睡眠时SaO 2下降幅度较小（3%-11%饱和度）。这些下降主要不是由于肺泡通气不足。有些慢性气道阻塞患者在夜间会出现严重的间歇性血氧饱和度下降，这种情况可以通过低流量O2给药得到缓解。
Arterial O2 saturation (SaO2) was monitored in 10 patients with severe chronic obstructive lung disease during 24 h of breathing room air followed by 24 h of breathing 2 l O2/min. Three subjects without chronic obstructive lung disease were monitored while breathing room air. Greatest declines in SaO2 occurred during sleep, with intermittent decreases as great as 44% saturation (range, 12%-44% saturation). Baseline SaO2 was significantly higher while patients breathed low-flow O2 (94% vs. 86% saturated), and declines in SaO2 during sleep were less noteworthy (1%-27% saturation). Subjects without chronic obstructive lung disease showed declines in SaO2 of much lesser magnitude (3%-11% saturation) with sleep. These declines were not primarily due to alveolar hypoventilation. There are patients with chronic airways obstruction who suffer profound intermittent desaturation at night that can readily be relieved with low-flow O2 administration.