The complex association between metabolic syndrome and male hypogonadism
The complex association between metabolic syndrome and male hypogonadism
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DOI：
10.1016/j.metabol.2018.03.024
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发表时间：
2018-09-01
影响因子：
9.8
通讯作者：
Maggi, Mario
中科院分区：
文献类型：
--
作者：
Dimopoulou, Christina;Goulis, Dimitrios G.;Maggi, Mario
背景：代谢综合征(METS)和男性性腺功能低下症之间的复杂联系已得到充分证实。大量的观察性研究表明，低睾酮水平与男性的胰岛素抵抗和糖尿病及蛋氨酸水平低下的风险增加有关。目的：为了阐明蛋氨酸与男性性腺功能减退症之间的关系，提供两种共病共存的流行病学数据，揭示其潜在的病理生理学，并评价睾酮补充疗法(TTH)和生活方式改变对男性的蛋氨酸和身体组成的影响。材料和方法：系统地搜索PubMed和Medline数据库中关于蛋氨酸和男性性腺功能减退相关性的出版物。结果：甲硫氨酸和男性性腺功能减退症在普通人群中的患病率很高，并且经常共存于男性糖尿病患者中。从动物和人类研究中积累的证据表明，蛋氨酸与男性性腺功能低下症的发病机制有关，反之亦然。另一方面，有证据表明，补充睾酮对患有METS和/或糖尿病的睾酮缺乏男性有良好的效果。结论：需要有更好的方法学特征的研究，以确定补充睾酮在男性METS和/或糖尿病中的作用。(C)2018 Elsevier Inc.保留所有权利。
Background: The complex association between metabolic syndrome (MetS) and male hypogonadism is well established. A number of observational studies show that low testosterone is associated with insulin resistance and an increased risk for diabetes mellitus and MetS in men.Aims: To elucidate the association between MetS and male hypogonadism, present epidemiological data on the co-existence of the two comorbidities, enlighten the underlying pathophysiology and appraise the effects of testosterone supplementation therapy (TTh) and lifestyle modifications on MetS and body composition in men.Materials and Methods: Systematic search to PubMed and Medline databases for publications reporting data on association between MetS and male hypogonadism.Results: Both MetS and male hypogonadism have a high prevalence in the general population and are frequently co-existing e.g. in males with diabetes. Accumulating evidence from animal and human studies suggests that MetS is involved in the pathogenesis of hypogonadism in males as well as the other way around. On the other hand, there is evidence for a favorable effect of testosterone supplementation in testosterone deficient men with MetS and/or diabetes mellitus.Conclusions: Studies with superior methodological characteristics are needed in order to establish a role for testosterone supplementation in men with MetS and/or diabetes mellitus. (C) 2018 Elsevier Inc. All rights reserved.