Prevalence of ectasia in human coronary arteries in patients in northern Greece referred for coronary angiography
Prevalence of ectasia in human coronary arteries in patients in northern Greece referred for coronary angiography
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DOI：
10.1016/j.amjcard.2006.02.034
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发表时间：
2006-08-01
影响因子：
2.8
通讯作者：
Louridas, George E.
中科院分区：
文献类型：
--
作者：
Giannoglou, George D.;Antoniadis, Antonios P.;Louridas, George E.
我们确定了冠状动脉扩张症(CAE)的患病率，并调查了其与冠状动脉造影意义重大的冠状动脉疾病(CAD)之间的潜在相关性。我们还检查了CAE和CAD是否在地形上相关。对1995年1月1日至2003年12月31日连续10,524例患者的冠状动脉造影进行分析，并对CAE病例进行识别、记录和总结。287例(2.7%)发生CAE。男性的发病率明显高于女性(p<；0.0001)。年轻患者表现出更高的CAE患病率(p<；0.01)，这在男性中得到了证实(p<；0.05)，但在女性中没有得到证实。CAE250例(87.1%)合并冠脉病变(P=0.001)。在整个研究过程中，冠心病显著增加(p<；0.001)，而CAE的患病率保持不变。冠脉病变在右冠状动脉的患病率显著高于左前降支和左回旋支(p<；0.0001)，而冠心病最常影响左前降支(p<；0.0001)。此外，右冠状动脉的CAE与LAD中冠心病的存在有很强的相关性(p=0.015)。总而言之，CAE在有右冠状动脉系统倾向的年轻男性中更为常见。虽然与CAD有关，但不能建立直接的因果关系。(C)2006 Elsevier Inc.保留所有权利。
We determined the prevalence of coronary artery ectasia (CAE) in patients who were referred to our institution for coronary angiography, for any reason and investigated its potential association with angiographically significant coronary artery disease (CAD). We also examined whether CAE and CAD are topographically associated. In 10,524 consecutive patients from January 1, 1995 to December 31, 2003, the corresponding coronary angiographies were analyzed and cases of CAE were identified, recorded, and summarized. CAE was found in 287 patients (2.7%). It was markedly more prevalent in men than in women (p < 0.0001). Younger patients exhibited a higher prevalence of CAE (p < 0.01), and this was confirmed for men (p < 0.05) but not for women. Co-existence with CAD was noted in 250 cases of CAE (87.1%) (p = 0.001). CAD increased remarkably throughout the study (p < 0.001), whereas the prevalence of CAE remained unchanged. The prevalence of CAE was significantly greater in the right coronary artery than in the left anterior descending (LAD) coronary artery and the left circumflex artery (p < 0.0001), whereas CAD most commonly affected the LAD (p < 0.0001). Further, CAE in the right coronary artery showed a strong association with the existence of CAD in the LAD (p = 0.015). In conclusion, CAE is more frequent in young men who show a predilection for the right coronary arterial system. Although associated with CAD, a direct causal relation cannot be established. (c) 2006 Elsevier Inc. All rights reserved.