Biomarkers of Exposure among US Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014)
Biomarkers of Exposure among US Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014)
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DOI：
10.1158/1055-9965.epi-18-0539
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发表时间：
2019-05-01
影响因子：
3.8
通讯作者：
van Bemmel, Dana M.
中科院分区：
文献类型：
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作者：
Chang, Cindy M.;Rostron, Brian L.;van Bemmel, Dana M.
背景：考虑到雪茄市场的多样化和雪茄类型生物标志物模式的有限数据，我们比较了雪茄吸烟者和其他群体的尼古丁和烟草毒物的生物标志物。方法：使用烟草与健康人口评估（PATH）研究中 5,604 名成年人的第一波尿液生物标志物数据，我们比较了只吸雪茄的吸烟者（所有雪茄以及传统雪茄、小雪茄和过滤雪茄）的几何平均浓度。雪茄）、只吸烟者、双雪茄/香烟吸烟者以及从不吸烟者。我们计算了对性别、年龄、种族/民族、教育程度和肌酸酐进行调整后从不吸雪茄的群体的几何平均比率。结果：有一天，只吸雪茄的人的生物标志物浓度比每天只吸雪茄的人低，但高于从不吸雪茄的人。与每天只吸香烟的人（n = 2217；P < 0.0001）和同时吸雪茄/香烟的人（n = 601；P < 0.0001）相比，每天只吸雪茄的人（n = 61）的 TNE-2（cotininethorntrans-3 0-羟基可替宁）较低。这些组中的几种生物标志物，包括 NNAL（NNK 代谢物）和 CYMA（丙烯腈代谢物），具有可比性。在探索性分析中，与每天只吸传统雪茄的吸烟者 (n = 12) 和只吸小雪茄的吸烟者 (n = 24) 相比，每天只吸过滤雪茄的吸烟者 (n = 7) 具有更高的生物标志物浓度。每天吸每种雪茄的人与只吸卷烟的人相似。对于一些生物标志物，特别是每天只吸过滤雪茄的吸烟者，浓度更高。结论：对于一些生物标志物，每天只吸雪茄的吸烟者与每天只吸香烟的人具有可比性。探索性分析表明，生物标志物因雪茄类型而异，每天只吸过滤雪茄的吸烟者的浓度最高。影响：雪茄吸烟者大量接触有害成分是一个持续的健康问题。
Background: Given the diverse cigar market and limited data on biomarker patterns by cigar type, we compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups.Methods: Using Wave 1 urinary biomarker data from 5,604 adults in the Population Assessment of Tobacco and Health (PATH) Study, we compared geometric mean concentrations among cigar-only smokers (all cigars and separately for traditional, cigarillo, and filtered cigars), cigarette-only smokers, dual cigar/cigarette smokers, and never users of tobacco. We calculated geometric mean ratios comparing groups with never users adjusting for sex, age, race/ethnicity, education and creatinine.Results: Some day cigar-only smokers had lower biomarker concentrations than every day cigar-only smokers, but higher than never users. Every day cigar-only smokers (n = 61) had lower TNE-2 (cotininethorntrans-3 0-hydroxycotinine) compared to every day cigarette-only (n = 2217; P < 0.0001) and dual cigar/cigarette smokers (n = 601; P < 0.0001). Several biomarkers, including NNAL (NNK metabolite) and CYMA (metabolite of acrylonitrile), were comparable in these groups. In exploratory analyses, every day filtered cigar-only (n = 7) smokers had higher biomarker concentrations compared with every day traditional cigar-only smokers (n = 12) and cigarillo-only smokers (n = 24). Every day smokers of each cigar type were similar to exclusive cigarette smokers. For some biomarkers, particularly for every day filtered cigar-only smokers, concentrations were higher.Conclusions: For some biomarkers, every day cigar-only smokers were comparable with every day cigarette-only smokers. Exploratory analyses suggest that biomarkers vary by cigar type with every day filtered cigar-only smokers having the highest concentrations.Impact: High exposure to harmful constituents among cigar smokers is a continuing health issue.