Bone Marrow Stromal Cells Control the Growth of Hepatic Stellate Cells In Vitro
Bone Marrow Stromal Cells Control the Growth of Hepatic Stellate Cells In Vitro
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DOI：
10.1007/s10620-008-0227-9
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发表时间：
2008-11-01
影响因子：
3.1
通讯作者：
Li, Hulun
中科院分区：
文献类型：
--
作者：
Shi, Lijun;Li, Guozhong;Li, Hulun
肝硬化的特点是肝功能不全，肝内纤维组织大量积聚。肝星状细胞（HSCs）是纤维基质蛋白的主要来源，在肝硬化的进展中起重要作用。在我们的研究中，骨髓基质细胞（BMSCs）抑制造血干细胞的生长。这种抑制是不可逆的，随后发生细胞凋亡。骨髓间充质干细胞对造血干细胞凋亡的影响可能是通过骨髓间充质干细胞分泌的神经生长因子（NGF）和肝细胞生长因子（HGF）激活的JNK通路。同时，转化生长因子- β阻断可增强细胞凋亡作用。
Liver cirrhosis is characterized by hepatic dysfunction, with extensive accumulation of fibrous tissue in the liver. Hepatic stellate cells (HSCs) are the major source of fibrillar matrix proteins and play an important role in the progress of liver cirrhosis. In our study, the growth of HSCs is inhibited by bone marrow stromal cells (BMSCs). The inhibition is irreversible and is followed by apoptosis. The effect of BMSCs on the apoptosis of HSCs is possibly via the JNK pathway activated by nerve growth factor (NGF) and hepatocyte growth factor (HGF) secreted by BMSCs. Meanwhile, the apoptosis effect is enhanced by transforming growth factor-beta blocking.