Siblings of patients with Haemophilus meningitis have impaired anticapsular antibody responses to Haemophilus vaccine.
Siblings of patients with Haemophilus meningitis have impaired anticapsular antibody responses to Haemophilus vaccine.
复制标题
嗜血杆菌脑膜炎患者的兄弟姐妹对嗜血杆菌疫苗的抗荚膜抗体反应受损。
DOI：
10.1016/s0022-3476(83)80342-4
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Suarez,B
中科院分区：
文献类型：
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作者：
Granoff,DM;Squires,JE;MunsonJr,RS;Suarez,B
b型流感嗜血杆菌脑膜炎患者的发作增加了发生嗜血杆菌病的风险。我们使用含有B型多糖胶囊（10 μg PRP）和百日咳疫苗（4个不透明单位）（Lederle Laboratories）的疫苗免疫26名健康同胞和25名对照受试者，以确定血友病脑膜炎患者的同胞是否对PRP的抗体应答受损。间隔一个月进行两次肌肉注射，我们发现兄弟姐妹对PRP的反应较低。第二次注射后一个月，24名兄弟姐妹中有12名血清抗囊膜（PRP）抗体浓度（≥300 ng/ml）足以提供对血友病的保护，而24名对照儿童中有19名（50% vs 79%，卡方分析P=0.035）。与正常对照组相比，同胞产生的IgG抗PRP抗体显着减少，但IgM的量相似。对PRP的反应性受损在其兄弟姐妹患有脑膜炎后出生的16名儿童中最为明显，并且这些儿童以前不知道曾暴露于b型嗜血杆菌感染。这些数据表明，某些b型嗜血杆菌脑膜炎患者的同胞形成IgG抗PRP抗体的能力降低，这可能与嗜血杆菌病的易感性增加有关。
Siblings of patients with type bHaemophilus influenzaemeningitis are at increased risk of developingHaemophilusdisease. We immunized 26 healthy siblings and 25 control subjects using a vaccine containing the type b polysaccharide capsule (10 μg PRP) and pertussis vaccine (4 opacity units) (Lederle Laboratories) to determine whether siblings of patients withHaemophilusmeningitis had an impaired antibody response to PRP. Using two intramuscular injections one month apart, we found that the siblings had a lower response to PRP. One month after the second injection, 12 of 24 of the siblings had serum concentrations of anticapsular (PRP) antibody though to be sufficient to confer protection againstHaemophilusdisease (≥300 ng/ml), compared with 19 of 24 of the control children tested (50% vs 79%, P=0.035 by chi-square analysis). In comparison with the normal controls, the siblings produced significantly less IgG anti-PRP antibody but similar amounts of IgM. The impaired responsiveness to PRP was most evident among the 16 children born after their sibling had meningitis and who were not known to have been exposed to type bHaemophilusinfection previously. These data indicate that siblings of some patients with type bHaemophilusmeningitis have reduced ability to form IgG anti-PRP antibody, which may be associated with increased susceptibility toHaemophilusdisease.