Extracellular vesicles and immune response during pregnancy: A balancing act.
Extracellular vesicles and immune response during pregnancy: A balancing act.
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怀孕期间的细胞外囊泡和免疫反应：平衡行为。
DOI：
10.1111/imr.13074
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发表时间：
2022-07
影响因子：
8.7
通讯作者：
中科院分区：
文献类型：
--
作者：
母体对半或完全同种异体胎儿耐受的机制正在深入研究。在整个妊娠期间，胎儿-胎盘抗原与母体免疫系统在滋养层-蜕膜界面内局部相互作用，并通过脱落细胞和与母体次级淋巴组织相互作用的可溶性分子远距离相互作用。细胞外囊泡（EV）作为抗原和免疫调节分子的局部或全身载体的发现为我们对植入前、滋养层侵入期间和整个妊娠过程中的免疫调节的理解增加了新的维度。关于免疫调节分子的新数据，位于EV上或其货物中，表明EV在妊娠期间谈判免疫耐受中的作用。来自移植免疫学领域的经验教训也揭示了胎儿胎盘来源的EV和母体淋巴组织之间可能的相互作用。这些见解阐明了电动汽车在重大产科疾病中的潜在作用。这篇综述提供了关于深入研究的妊娠相关EV及其货物分子和胎儿-胎盘-母体贩运模式的最新信息，突出了可能成为妊娠健康和疾病免疫抑制或激活基础的潜在免疫途径。我们的总结还强调了可能需要将母胎界面的定义扩展到可能与循环EV相互作用的全身性母体免疫组织。
The mechanisms underlying maternal tolerance of the semi- or fully-allogeneic fetus are intensely investigated. Across gestation, feto-placental antigens interact with the maternal immune system locally within the trophoblast-decidual interface and distantly through shed cells and soluble molecules that interact with maternal secondary lymphoid tissues. The discovery of extracellular vesicles (EVs) as local or systemic carriers of antigens and immune-regulatory molecules has added a new dimension to our understanding of immune modulation prior to implantation, during trophoblast invasion, and throughout the course of pregnancy. New data on immune regulatory molecules, located on EVs or within their cargo suggest a role for EVs in negotiating immune tolerance during gestation. Lessons from the field of transplant immunology also shed light on possible interactions between feto-placentally derived EVs and maternal lymphoid tissues. These insights illuminate a potential role for EVs in major obstetrical disorders. This review provides updated information on intensely studied, pregnancy-related EVs, their cargo molecules, and patterns of fetal-placental-maternal trafficking, highlighting potential immune pathways that might underlie immune suppression or activation in gestational health and disease. Our summary also underscores the likely need to broaden the definition of the maternal-fetal interface to systemic maternal immune tissues that might interact with circulating EVs.
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作者：
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发表时间：
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