Prolonged Leucine Supplementation Does Not Augment Muscle Mass or Affect Glycemic Control in Elderly Type 2 Diabetic Men
Prolonged Leucine Supplementation Does Not Augment Muscle Mass or Affect Glycemic Control in Elderly Type 2 Diabetic Men
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DOI：
10.3945/jn.111.138495
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发表时间：
2011-06-01
影响因子：
4.2
通讯作者：
van Loon, Luc J. C.
中科院分区：
文献类型：
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作者：
Leenders, Marika;Verdijk, Lex B.;van Loon, Luc J. C.
随着年龄的增长，肌肉质量的损失至少部分归因于对食物摄入的肌肉蛋白质合成反应迟钝。据报道，亮氨酸充血可刺激餐后胰岛素释放并增加餐后肌肉蛋白质的增加。我们评估了老年2型糖尿病患者补充亮氨酸6个月的临床益处。60名老年男性2型糖尿病患者（年龄71 ± 1岁，体重指数27.3 ± 0.4 kg/m2）在6个月的营养干预（7.5 g/d亮氨酸或安慰剂）期间，每顿主餐给予2.5 g L-亮氨酸（n = 30）或安慰剂（n = 30）。身体成分，肌纤维特征，肌肉力量，葡萄糖稳态，基础血浆氨基酸和脂质浓度进行了评估之前，期间和之后的干预。两组间的瘦组织质量没有变化或差异，在0、3和6个月时，亮氨酸组分别为61.9 +/- 1.1、62.2 +/- 1.1和62.0 +/- 1.0 kg，安慰剂组分别为62.2 +/- 1.3、62.2 +/- 1.3和62.2 +/- 1.3 kg。体脂百分比、肌肉力量和肌纤维类型特征也没有变化。两组之间的血液糖化血红蛋白没有变化或差异，亮氨酸组为7.1 +/- 0.1%，安慰剂组为7.2 +/- 0.2%。与此一致，口服葡萄糖胰岛素敏感性和血脂浓度没有变化或组间差异。我们的结论是，长期补充亮氨酸（7.5克/天）不调节身体成分，肌肉质量，力量，血糖控制，和/或糖尿病的老年人，2型糖尿病患者习惯性地消耗足够的膳食蛋白质。J.营养141：1070-1076，2011.
The loss of muscle mass with aging has been, at least partly, attributed to a blunted muscle protein synthetic response to food intake. Leucine congestion has been reported to stimulate postprandial insulin release and augment postprandial muscle protein accretion. We assessed the clinical benefits of 6 mo of leucine supplementation in elderly, type 2 diabetes patients. Sixty elderly males with type 2 diabetes (age, 71 +/- 1 y; BMI, 27.3 +/- 0.4 kg/m(2)) were administered 2.5 g L-leucine (n = 30) or a placebo (n = 30) with each main meal during 6 mo of nutritional intervention (7.5 g/d leucine or placebo). Body composition, muscle fiber characteristics, muscle strength, glucose homeostasis, and basal plasma amino acid and lipid concentrations were assessed prior to, during, and after intervention. Lean tissue mass did not change or differ between groups and at 0, 3, and 6 mo were 61.9 +/- 1.1, 62.2 +/- 1.1, and 62.0 +/- 1.0 kg, respectively, in the leucine group and 62.2 +/- 1.3, 62.2 +/- 1.3, and 62.2 +/- 1.3 kg in the placebo group. There also were no changes in body fat percentage, muscle strength, and muscle fiber type characteristics. Blood glycosylated hemoglobin did not change or differ between groups and was 7.1 +/- 0.1% in the leucine group and 7.2 +/- 0.2% in the placebo group. Consistent with this, oral glucose insulin sensitivity and plasma lipid concentrations did not change or differ between groups. We conclude that prolonged leucine supplementation (7.5 g/d) does not modulate body composition, muscle mass, strength, glycemic control, and/or lipidemia in elderly, type 2 diabetes patients who habitually consume adequate dietary protein. J. Nutr. 141: 1070-1076, 2011.